23530-47-4

Basic information

• Product Name: 4-Nitro-N-propylbenzenesulfonaMide, 97%
• Synonyms: 4-Nitro-N-propylbenzenesulfonaMide, 97%
• CAS NO: 23530-47-4
• Molecular Formula: C₉H₁₂N₂O₄S
• Molecular Weight: 244.26758
• Mol File: 23530-47-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 395.5°C at 760 mmHg
• Flash Point: 193°C
• Appearance: /
• Density: 1.321g/cm³
• Vapor Pressure: 1.82E-06mmHg at 25°C
• Refractive Index: 1.552
• CAS DataBase Reference: 4-Nitro-N-propylbenzenesulfonaMide, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Nitro-N-propylbenzenesulfonaMide, 97%(23530-47-4)
• EPA Substance Registry System: 4-Nitro-N-propylbenzenesulfonaMide, 97%(23530-47-4)

Safety Data

• Hazardous Substances Data: 23530-47-4(Hazardous Substances Data)

Usage

General Description

4-Nitro-N-propylbenzenesulfonamide, 97% is a chemical compound that is primarily used as a sulfonamidamide intermediate in the production of pharmaceuticals. It is a white to light yellow crystalline powder with a purity of 97%, making it suitable for use in various synthesis processes. 4-Nitro-N-propylbenzenesulfonaMide, 97% is known for its role as an inhibitor of the enzyme carbonic anhydrase, and it is also used in the development of antitumor agents. Additionally, it has applications in the field of agrochemicals and dye production. Overall, 4-Nitro-N-propylbenzenesulfonamide, 97% is a versatile chemical with diverse uses in the pharmaceutical and chemical industries.

InChI:InChI=1/C9H12N2O4S/c1-2-7-10-16(14,15)9-5-3-8(4-6-9)11(12)13/h3-6,10H,2,7H2,1H3

Upstream product

• 107-10-8 propylamine 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 156840-00-5 2,4-dinitrophenyl 4-nitrobenzenesulfonate 

Downstream Products

• 58687-83-5 4-amino-N-propylbenzenesulfonamide 
• 1392414-69-5 (Z)-N-(1-bromo-1-octen-2-yl)-N-propyl-p-nitrobenzenesulfonamide 

Relevant articles and documents

AMIDE-LINKED, AMINOBENZAZEPINE IMMUNOCONJUGATES, AND USES THEREOF

The invention provides immunoconjugates of Formula I comprising an antibody linked by conjugation to one or more 8-amido-2-aminobenzazepine derivatives. The invention also provides 8-amido-2-aminobenzazepine derivative intermediate compositions comprising a reactive functional group. Such intermediate compositions are suitable substrates for formation of the immunoconjugates through a linker or linking moiety. The invention further provides methods of treating cancer with the immunoconjugates.

Metal-Free β-Amino Alcohol Synthesis: A Two-step Smiles Rearrangement

A novel method for the synthesis of β-amino alcohols has been demonstrated under mild reaction conditions with a broad scope via a two-step Smiles rearrangement. What is more, theoretical calculations have been performed to confirm the rationality of the mechanism. The method has been proved to be notably effective for N-arylated amino alcohols, which are difficult to synthesize by traditional methods.

Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists

To date, many known G protein-coupled receptor 55 (GPR55) ligands are those identified among the cannabinoids. In order to further study the function of GPR55, new potent and selective ligands are needed. In this study, we utilized the screening results from PubChem bioassay AID 1961 which reports the results of Image-based HTS for Selective Agonists of GPR55. Three compounds, CID1792579, CID1252842 and CID1011163, were further evaluated and used as a starting point to create a series of nanomolar potency GPR55 agonists with N-(4-sulfamoylphenyl)thiourea scaffold. The GPR55 activity of the compounds were screened by using a commercial β-arrestin PathHunter assay and the potential compounds were further evaluated by using a recombinant HEK cell line exhibiting GPR55-mediated effects on calcium signalling. The designed compounds were not active when tested against various endocannabinoid targets (CB1R, CB2R, FAAH, MGL, ABHD6 and ABHD12), indicating compounds' selectivity for the GPR55. Finally, structure-activity relationships of these compounds were explored.