23536-75-6

Basic information

• Product Name: 4-HYDROXY-5-NITROQUINOLINE
• Synonyms: 4-HYDROXY-5-NITROQUINOLINE;5-Nitroquinolin-4-ol
• CAS NO: 23536-75-6
• Molecular Formula: C9H6N2O3
• Molecular Weight: 190.16
• Mol File: 23536-75-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-HYDROXY-5-NITROQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXY-5-NITROQUINOLINE(23536-75-6)
• EPA Substance Registry System: 4-HYDROXY-5-NITROQUINOLINE(23536-75-6)

Safety Data

• Hazardous Substances Data: 23536-75-6(Hazardous Substances Data)

Upstream product

• 7613-19-6 5-nitro-quinoline-1-oxide 
• 607-34-1 5-nitroquinoline 
• 611-35-8 4-chloroquinoline 
• 2033-24-1 cycl-isopropylidene malonate 
• 99-09-2 3-nitro-aniline 
• 40106-98-7 4-chloro-5-nitroquinoline 

Relevant articles and documents

Assembly of 4-aminoquinolines via palladium catalysis: A mild and convenient alternative to SNAr methodology

4-Aminoquinolines, classically prepared via SNAr chemistry from an amine and 4-haloquinoline, are important scaffolds in medicinal chemistry. Interest in these compounds prompted us to explore palladium catalysis as an alternative to the existing methods for their preparation. Initial results followed by an iterative screening paradigm confirmed Pd(OAc)2/ DPEphos/K3PO4 as a mild and convenient alternative for the formation of the C-N bond in 4-aminoquinolines. A description of the screen and the scope of this methodology are discussed herein.