23536-76-7

Basic information

• Product Name: 7-BroMo-pyrido[1,2-a]pyriMidin-4-one
• Synonyms: 7-BroMo-pyrido[1,2-a]pyriMidin-4-one
• CAS NO: 23536-76-7
• Molecular Formula: C₈H₅BrN₂O
• Molecular Weight: 225.0421
• Mol File: 23536-76-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 278.6±50.0 °C(Predicted)
• Appearance: /
• Density: 1.73±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.76±0.50(Predicted)
• CAS DataBase Reference: 7-BroMo-pyrido[1,2-a]pyriMidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-BroMo-pyrido[1,2-a]pyriMidin-4-one(23536-76-7)
• EPA Substance Registry System: 7-BroMo-pyrido[1,2-a]pyriMidin-4-one(23536-76-7)

Safety Data

• Hazardous Substances Data: 23536-76-7(Hazardous Substances Data)

Usage

General Description

7-Bromo-pyrido[1,2-a]pyrimidin-4-one is a chemical compound with the molecular formula C8H5BrN2O. It is a heterocyclic aromatic compound with a pyrimidine ring fused to a pyridine ring, and a bromine atom attached at the 7th position of the pyridine ring. 7-BroMo-pyrido[1,2-a]pyriMidin-4-one has potential pharmaceutical applications and is commonly used as a building block in the synthesis of various biologically active molecules. Its structure and properties make it a valuable tool in drug discovery and development, as well as in the study of chemical reactions and mechanisms in organic chemistry.

Upstream product

• 1072-97-5 5-bromo-2-pyridylamine 
• 25165-70-2 5-[(5-Bromo-pyridin-2-ylamino)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione 

Downstream Products

• 1848242-58-9 N-(5-{3-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl}-2-methoxypyridin-3-yl)-2,4-difluorobenzenesulfonamide 

Relevant articles and documents

Design, synthesis and biological evaluations of a series of Pyrido[1,2-a]pyrimidinone derivatives as novel selective FGFR inhibitors

Aberrant signaling of fibroblast growth factor receptors (FGFRs) has been identified as a driver of tumorigenesis and the development of many solid tumors, making FGFRs a compelling target for anticancer therapy. Herein, we describe the design and synthes

PYRIDO[1,2-a]PYRIMIDONE DERIVATIVES AS A mTOR/PI3K SUPPRESSOR

The invention discloses pyrido[1,2-a]pyrimidone derivatives as a mTOR/PI3K suppressor; and in particular, this invention relates to a compound having the formula (I) structure or its pharmaceutically acceptable salts.

Exotic amino acids. 6. Synthesis of substituted 4-oxo-4H-pyrido[1,2-a]pyrimidines

2-Pyridylaminomethyleneisopropylidenemalonates, prepared from ethoxymethyleneisopropylidenemalonate and 2-aminopyridines, form 4-oxo-4H-pyrido[1,2-a] pyrimidines at their melting points and are separated from the reaction mixture by sublimation.