2354-61-2

Basic information

• Product Name: 1-Butanone, 1-(4-fluorophenyl)-4-(4-phenyl-1-piperazinyl)-
• Synonyms: 1-Butanone, 1-(4-fluorophenyl)-4-(4-phenyl-1-piperazinyl)-;1-(4-Fluorophenyl)-4-(4-phenyl-1-piperazinyl)-1-butanone;Butropipazon
• CAS NO: 2354-61-2
• Molecular Formula: C₂₀H₂₃FN₂O
• Molecular Weight: 326.45
• Mol File: 2354-61-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 481.2°Cat760mmHg
• Flash Point: 244.8°C
• Appearance: /
• Density: 1.1177 (estimate)
• Vapor Pressure: 2.03E-09mmHg at 25°C
• Refractive Index: 1.565
• CAS DataBase Reference: 1-Butanone, 1-(4-fluorophenyl)-4-(4-phenyl-1-piperazinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Butanone, 1-(4-fluorophenyl)-4-(4-phenyl-1-piperazinyl)-(2354-61-2)
• EPA Substance Registry System: 1-Butanone, 1-(4-fluorophenyl)-4-(4-phenyl-1-piperazinyl)-(2354-61-2)

Safety Data

• Hazardous Substances Data: 2354-61-2(Hazardous Substances Data)

Usage

Uses

Butropipazon is derived from 1-Phenylpiperazine (P336040), which was tested for its activity as a topical glaucoma agent.

InChI:InChI=1/C20H23FN2O/c21-18-10-8-17(9-11-18)20(24)7-4-12-22-13-15-23(16-14-22)19-5-2-1-3-6-19/h1-3,5-6,8-11H,4,7,12-16H2

Upstream product

• 6303-21-5 hypophosphorous acid 

Relevant articles and documents

Piperazinobutyrophenone derivatives

Central nervous system active butyrophenone derivatives in which γ -piperazinobutyrophenone derivatives of the formula, SPC1 Wherein R1 is hydrogen, amino, C1 -C5 alkanoylamino, C1 -C4 alkylamino or N-(C1 -C4 alkyl)(C1 -C5 alkanoyl) amino; R2 is hydrogen or halogen; R3 is hydrogen, halogen, C1 -C4 alkyl, C1 -C4 alkoxy or trifluoromethyl; and m is 0, 1 or 2, and acid addition salts thereof, can be prepared by reacting an indole derivative of the formula, SPC2 Wherein R2, R3 and m are the same as defined above, and R4 and R5 are hydrogen or C1 -C4 alkyl respectively, with an oxidizing agent to yield an o-alkanoylamino-γ-piperazinobutyrophenone derivative of the formula, SPC3 Wherein R2, R3, R4, R5 and m are the same as defined above, and further, if necessary, hydrolyzing the product to yield an o-amino-γ-piperazinobutyrophenone derivative of the formula, SPC4 Wherein R2, R3, R5 and m are the same as defined above, and further diazotizing, if desired, in case R5 is hydrogen, the obtained o-amino-γ-piperazinobutyrophenone derivative and subsequently decomposing the resultant diazonium compound to replace the diazonium group by hydrogen. Among the butyrophenone derivatives thus obtained, those in which R1 is amino, alkanoylamino, alkylamino or N-alkylalkanoylamino and those in which R1 is hydrogen and R2 is halogen substituted at meta-position to carbonyl group are novel compounds.