23557-81-5

Upstream product

• 100-47-0 benzonitrile 
• 95-76-1 m,p-dichloroaniline 

Downstream Products

• 74063-15-3 6,7-dichloro-3-phenyl-1,2,4-benzothiadiazine 1-oxide 
• 1449576-70-8 6,7-dichloro-2-phenyl-3H-imidazo[4,5-b]quinoline-9-carbonitrile 
• 1449576-73-1 7,8-dichloro-2-phenyl-3H-imidazo[4,5-b]quinoline-9-carbonitrile 
• 1449612-23-0 (Z)-2-{4-[(3,4-dichlorophenyl)imino]-2-phenyl-1H-imidazol-5(4H)-ylidene}malononitrile 
• 1449576-61-7 2-[1-(3,4-dichlorophenyl)-5-imino-2-phenyl-1H-imidazol-4(5H)-ylidene]malononitrile 
• 1449612-14-9 N′-(3,4-dichlorophenyl)-N-(1,2,2-tricyanovinyl)benzamidine 

Relevant academic research and scientific papers

Synthesis of 1,2-dihydro-1,3,5-triazine derivativesviaCu(ii)-catalyzed C(sp3)-H activation ofN,N-dimethylethanolamine with amidines

1,2-Dihydro-1,3,5-triazines and symmetrical 1,3,5-triazines were obtained in up to 81% yields from amidines andN,N-dimethylethanolamine catalyzed by CuCl2. The reaction involves three C-N bond formations during the oxidative annulation process

Metal-Free C-B Bond Cleavage: An Acid Catalyzed Three-Component Reaction Construction of Imidazole-Containing Triarylmethanes

An efficient acid-catalyzed strategy to prepare imidazole-containing triarylmethanes from amidines, ynals, and boronic acids has been developed. It represents an unprecedented and novel metal-free C-B bond cleavage strategy as a workable route to form new carbon-carbon bonds.

Transition-metal-free three-component reaction: Additive controlled synthesis of sulfonylated imidazoles

Two efficient transition-metal-free highly regioselective pathways for constructing sulfonylated imidazoles via three-component reactions of amidines, ynals, and sodium sulfonates have been developed. The generations of different sulfonylated imidazoles w

Substrate-Controlled Selectivity Switch in a Three-Component Reaction: A Ag-Catalyzed Strategy for the Synthesis of Functionalized Imidazoles

An efficient Ag-catalyzed three-component reaction of amidines, ynals, and alcohols, phenols, or water has been developed. This strategy provides a wide range of substrates and represents a simple process for the preparation of different imidazole derivatives in good yields with high regioselectivities.

Reinvestigating the synthesis of N-arylbenzamidines from benzonitriles and anilines in the presence of AlCl3

The preparation of N-phenylbenzamidine 3a from the reaction between benzonitrile Ia and aniline in the presence of AId3 is reinvestigated with respect to mode of reagent addition, reaction temperature and Lewis acid catalysis. Pre-forming the nitrile-Lewis acid complex prior to the addition of aniline allows for milder reaction conditions, allowing for the higher yielding synthesis of N-phenylbenzamidine 3a (83%). Using these modified conditions several N-(4-substituted phenyl)benzamidines can be prepared including the N-(4-methoxyphenyl)benzamidine 3b (93%) and the previously unobtainable 2-amino-N-(4-methoxyphenyl)benzamidine 31(56%). All new compounds are fully characterised.