23559-91-3

Basic information

• Product Name: methyl (9R)-9-{[(4-methylphenyl)sulphonyl] oxy}octadecanoate
• Synonyms: methyl (9R)-9-{[(4-methylphenyl)sulphonyl] oxy}octadecanoate
• CAS NO: 23559-91-3
• Molecular Weight: 468.698
• Mol File: 23559-91-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl (9R)-9-{[(4-methylphenyl)sulphonyl] oxy}octadecanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (9R)-9-{[(4-methylphenyl)sulphonyl] oxy}octadecanoate(23559-91-3)
• EPA Substance Registry System: methyl (9R)-9-{[(4-methylphenyl)sulphonyl] oxy}octadecanoate(23559-91-3)

Safety Data

• Hazardous Substances Data: 23559-91-3(Hazardous Substances Data)

Upstream product

• 115185-06-3 9-Hode 
• 6114-37-0 methyl (9R)-9-hydroxyoctadecanoate 
• 98-59-9 p-toluenesulfonyl chloride 
• 23559-94-6 (+)-methyl 9(S)-hydroxyoctadecanoate 

Relevant articles and documents

Synthesis of 9-hydroxystearic acid derivatives and their antiproliferative activity on HT 29 cancer cells

9-Hydroxystearic acid (9-HSA) is an endogenous cellular lipid that possesses antiproliferative and selective effects against cancer cells. A series of derivatives were synthesized in order to investigate the effect of the substituent in position 9 and on the methyl ester functionality on the biological activity. The two separate enantiomers of methyl 9-hydroxystearate and of methyl 9-aminostearate showed antiproliferative activity against the HT29 cell line. This indicates the importance of position 9 groups being able to make hydrogen bonding with the molecular target. Further, this effect must be preserved when the carboxy group of 9-HSA is esterified. The biological tests showed that the amines, contrarily to methyl esters, resulted in cytotoxicity. A deep investigation on the effect of methyl (R)-9-hydroxystearate on HT29 cells showed an antiproliferative effect acting through the CDKN1A and MYCBP gene expression.

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