23569-56-4Relevant academic research and scientific papers
A new regio- and chemoselective approach to β-keto amides and β-enamino carboxamides via 1,3,2-dioxaborinanes
?tefane, Bogdan,Polanc, Slovenko
, p. 698 - 702 (2004)
Surprisingly, 5,6-disubstituted 2,2-difluoro-4-alkoxy-1,3,2-dioxaborinanes, which can be easily obtained from β-keto esters, reacted regio- and chemoselectively with amines under mild reaction conditions to form 2,2-difluoro-4-alkylamino-1,3,2-dioxaborina
Aminolysis of 2,2-difluoro-4-alkoxy-1,3,2-dioxaborinanes: route to β-keto amides and β-enamino carboxamides
?tefane, Bogdan,Polanc, Slovenko
, p. 10902 - 10913 (2008/02/12)
4-Alkoxy substituted 1,3,2-dioxaborinanes 1, readily available from β-keto esters, undergo substitution reactions under mild reaction conditions with primary and secondary amines, deriving the 4-alkylamino analogue 2. Reactions of 1 with substituted phenylhydrazines gave the corresponding hydrazones, or pyrazolones, and 5-alkoxy-1H-pyrazoles as a mixture of products.
