235785-92-9Relevant academic research and scientific papers
PROCESS FOR PREPARING INTERMEDIATES
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Page 22, (2008/06/13)
The present invention is directed to a process for preparing intermediates that are useful to prepare certain antibacterial N-formyl hydroxylamine compounds which are peptide deformylase inhibitors. The process makes use α β-lactam intermediate. Certain o
Asymmetric synthesis of BB-3497 - A potent peptide deformylase inhibitor
Pratt, Lisa M.,Beckett, R. Paul,Davies, Stephen J.,Launchbury, Steven B.,Miller, Andrew,Spavold, Zoe M.,Todd, Richard S.,Whittaker, Mark
, p. 2585 - 2588 (2007/10/03)
By screening a library of metalloenzyme inhibitors, the N-formyl-hydroxylamine derivative BB-3497 was identified as a potent inhibitor of Escherichia coli peptide deformylase with antibacterial activity both in vitro and in vivo. The homochiral synthesis of BB-3497, involving a novel asymmetric Michael addition reaction is described.
