23593-76-2

Usage

Class

Imidazole derivatives

Structural feature

Presence of a 1-[(3-chlorophenyl)diphenylmethyl] group attached to the imidazole ring

Potential applications

Medicinal chemistry and pharmaceutical research

Reasons for potential applications

Structural features and presence of chlorophenyl and diphenylmethyl groups that can impart specific biological activities or pharmacological properties

Additional research needed

Synthetic pathways, biological activities, and potential uses in various scientific and industrial fields.

Upstream product

• 288-32-4 1H-imidazole 
• 59154-29-9 (3-chlorophenyl)(diphenyl)methyl chloride 
• 29647-82-3 (3-chlorophenyl)(diphenyl)methanol 

Relevant academic research and scientific papers

Chemical compounds having ion channel blocking activity for the treatment of immune dysfunction

The present invention relates to chemical compounds having inhibitory activity on an intermediate conductance Ca 2+ activated potassium channel (IK Ca), and the use of such compounds for the treatment or alleviation of diseases or conditions relating to immune dysfunction. Moreover, the invention relates to a method of screening a chemical compound for inhibitory activity on an intermediate conductance Ca 2+ activated potassium channel (IK Ca).

Synthesis and antifungal activity of a series of difluorotritylimidazoles

1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole (flutrimazole, UR-4056, CAS 119006-77-8) (15) was selected among a series of mono-, di- and trifluorotrityl-imidazole antifungal agents as the most potent fluorine containing analogue of clotrimazole.