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Usage

Uses

Used in Acute Toxicologic Evaluation:
Hexamethylenebis(nitrilodimethylene)tetraphosphonic acid is used as a component in the acute toxicologic evaluation of DEQUEST 2051, a product used for controlling scale and corrosion in various water systems. Its role in this application is to provide effective chelation of metal ions, thus preventing their accumulation and potential toxic effects.
Used in Tartar Formation Inhibition Compositions:
In the dental industry, HMT is utilized as an active ingredient in tartar control products. It functions as a tartar formation inhibitor by chelating calcium ions, which are essential for the formation of dental calculus. This application helps maintain oral hygiene and prevents the buildup of tartar on teeth.
Used in Studies of Calcium Oxalate Crystal Growth Inhibition:
Hexamethylenebis(nitrilodimethylene)tetraphosphonic acid is employed in research focused on the inhibition of calcium oxalate crystal growth. Hexamethylenebis(nitrilodimethylene)tetraphosphonic acid is particularly useful in the study of kidney stone formation, as it can effectively bind to calcium ions and prevent the nucleation and growth of calcium oxalate crystals, which are the primary component of most kidney stones.

Upstream product

• 124-09-4 1,6-Hexanediamine 
• 50-00-0 formaldehyd 

Relevant academic research and scientific papers

Synthesis, breathing, and gas sorption study of the first isoreticular mixed-linker phosphonate based metal-organic frameworks

The synthesis of the first water stable isoreticular phosphonate based mixed-linker metal-organic frameworks (MOFs) is achieved via the use of the N-donor heterocyclic co-ligands. Furthermore, these isoreticular phosphonate frameworks show selective CO2/N2 uptake at low pressures.

Structure-Dependent Dissolution and Restructuring of Calcite Surfaces by Organophosphonates

Organophosphonates are well-known to strongly interact with the surfaces of various minerals, such as brucite, gypsum, and barite. In this work, we study the influence of six systematically varied organophosphonate molecules (tetraphosphonates and diphosphonates) on the dissolution process of the (10.4) surface of calcite. In order to pursue a systematic study, we have selected organophosphonates that exhibit similar structural features, but also systematic architectural differences. The effect of this class of additives on the dissolution process of the calcite (10.4) surface is evaluated using in situ dynamic atomic force microscopy. For all of the six organophosphonate derivatives, we observe a pronounced restructuring of the (10.4) cleavage plane of calcite, demonstrated by the formation of characteristically shaped etch pits. To elucidate their specific influence on the dissolution process of calcite (10.4), we vary systematically the number of functional end groups (two for the tetraphosphonates and one for the diphosphonates), the spacing between the functional ends through separating methylene groups (2, 6, and 12), as well as the pH of the solution (ranging from 2.6 up to 11.7). For each of the two groups of the organophosphonate derivatives, we observe the very same formation of etch pits (olive-shaped for the tetraphosphonate and triangular-shaped for the diphosphonate molecules), respectively. This finding indicates that the number of functional ends decisively determines the resulting calcite (10.4) surface morphology, whereas the size of the organophosphonate molecule within one group seems not to play any important role. For all of the molecules, the restructuring process of calcite (10.4) is qualitatively independent of the pH of the solution and, therefore, independent of the protonation/deprotonation states of the molecules. Our results reveal a general property of organophosphonate derivatives to induce surface restructuring of the calcite (10.4), which seems to be very robust against variations in both, different molecular structures and different protonation/deprotonation states.