236098-07-0Relevant articles and documents
Inhibition of the HIV-1 Rev-RRE complex formation by unfused aromatic cations
Xiao, Ge,Kumar, Arvind,Li, Ke,Rigl, C. Ted,Bajic, Miroslav,Davis, Tina M.,Boykin, David W.,Wilson, W. David
, p. 1097 - 1113 (2001)
RNA viruses cause a wide range of human diseases. Development of new agents to target such viruses is an active area of research. Towards this goal, a series of diphenylfuran cations as potential inhibitors of the Rev-RRE complex have been designed and synthesized. Analysis of the interaction of the diphenylfurans with RRE and TAR RNA model systems by gel shift assays indicates that they exhibit both sequence and structure-dependent binding modes. Our results show a strong interaction between the diphenylfuran ring system and RRE bases, while the TAR interactions are much weaker with the compounds that are the best inhibitors of Rev-RRE.
2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents
Boykin, David W.,Kumar, Arvind,Xiao, Ge,Wilson, W. David,Bender, Brendan C.,McCurdy, Donald R.,Hall, James Edwin,Tidwell, Richard R.
, p. 124 - 129 (2007/10/03)
The syntheses of 12 new 2,5-bis[4-(N-alkylamidino)phenyl]furans are reported. The interaction of these dicationic furans with poly(dA-dT) and with the duplex oligomer d(CGCGAATTCGCG)2 was determined by T(m) measurements, and the effectiveness o
