236115-82-5Relevant articles and documents
Design and synthesis of new aminoglycoside antibiotics containing neamine as an optimal core structure: Correlation of antibiotic activity with in vitro inhibition of translation
Greenberg, William A.,Priestley, E. Scott,Sears, Pamela S.,Alper, Phil B.,Rosenbohm, Christoph,Hendrix, Martin,Hung, Shang-Cheng,Wong, Chi-Huey
, p. 6527 - 6541 (1999)
The structure and activity of the pseudodisaccharide core found in aminoglycoside antibiotics was probed with a series of synthetic analogues in which the position of amino groups was varied around the glucopyranose ring. The naturally occurring structure
Design of small molecules that recognize RNA: Development of aminoglycosides as potential antitumor agents that target oncogenic RNA sequences
Sucheck, Steven J.,Greenberg, William A.,Tolbert, Thomas J.,Wong, Chi-Huey
, p. 1080 - 1084 (2007/10/03)
Functional single-stranded oncogenic mRNAs such as the breakpoints of the PAX3-FKHR and Bcr-Abl oncogenes bind selectively and with high affinity to naturally occurring, as well as synthetic, aminoglycosides. The latter, neamine-derived compounds were des