236123-65-2Relevant academic research and scientific papers
Stereoselective synthesis of chiral 3,4,5-trisubstituted 1,5- dihydropyrrol-2-ones from azadienes
Bandini, Elisa,Martelli, Giorgio,Spunta, Giuseppe,Bongini, Alessandro,Panunzio, Mauro,Piersanti, Giovanni
, p. 1445 - 1449 (2007/10/03)
A new access to enantiopure 3-phthalimido-4-amino-5-(1-hydroxyalkyl) 1,5-dihydropyrrol-2-ones has been developed from 1,3-azadienes. Stereoselective Lewis acid catalyzed addition of a cyano group to an azadiene, followed by intramolecular ring closure, in a four-step one-pot synthesis, results in the formation of γ-lactams in satisfactory yields.
