23630-48-0

Upstream product

• 202344-35-2 1-((2-chlorophenyl)methyl)-1H-pyrazole 
• 1252590-69-4 2-((1H-pyrazol-1-yl)methyl)phenyl methanesulfonate 
• 1185340-93-5 1-(2-bromobenzyl)-1H-pyrazole 
• 1218795-13-1 1-((2-iodophenyl)methyl)-1H-pyrazole 

Relevant academic research and scientific papers

Direct synthesis of pyrazolo[5,1-a]isoindoles via intramolecular palladium-catalyzed C-H bond activation

An efficient, direct synthesis of pyrazolo-[5,1-a]isoindoles employing a palladium-catalyzed intramolecular C-H bond activation of 1-(2-halobenzyl) pyrazoles has been developed. The use of lithium chloride (LiCl) was found to be essential in these reactions, to suppress further C-H bond activation at the C-3 position of pyrazolo[5,1-a]isoindole, when C-3 is unsubstituted. This protocol can be applied to the synthesis of a pyrazolo[5,1-a]isoquinoline possessing a six-membered central ring system and a fully substituted pyrazolo[5,1-a]isoindole using sequential intra- and intermolecular C-H bond activation.