17-Ethinyl-17-hydroxy-18-methylestra-5(10),9(11)-dien-3-one-3-ethylene ketal is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceuticals. It is characterized by its unique molecular structure, which includes an ethinyl group, a hydroxy group, and a ketal functional group. 17-Ethinyl-17-hydroxy-18-methylestra-5(10),9(11)-dien-3-one-3-ethylene ketal plays a significant role in the development of medications with potent therapeutic properties.
23637-79-8
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Basic information
- Product Name: 17-Ethinyl-17-hydroxy-18-methylestra-5(10),9(11)-dien-3-one-3-ethylene ketal
- Synonyms: 17-Ethinyl-17-hydroxy-18-methylestra-5(10),9(11)dien-3-one-3-ethylene ketal;17-Ethinyl-18-methylestra-5(10),9(11)dien-17-ol-3-one-3-ethylene
- CAS NO:23637-79-8
- Molecular Formula: C23H30O3
- Molecular Weight: 354.487
- EINECS: N/A
- Product Categories: N/A
- Mol File: 23637-79-8.mol
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Chemical Properties
- Melting Point: 172 °C(Solv: isopropyl ether (108-20-3))
- Boiling Point: 508.9±50.0 °C(Predicted)
- Flash Point: N/A
- Appearance: /
- Density: 1.20
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- PKA: 13.01±0.40(Predicted)
- CAS DataBase Reference: 17-Ethinyl-17-hydroxy-18-methylestra-5(10),9(11)-dien-3-one-3-ethylene ketal(CAS DataBase Reference)
- NIST Chemistry Reference: 17-Ethinyl-17-hydroxy-18-methylestra-5(10),9(11)-dien-3-one-3-ethylene ketal(23637-79-8)
- EPA Substance Registry System: 17-Ethinyl-17-hydroxy-18-methylestra-5(10),9(11)-dien-3-one-3-ethylene ketal(23637-79-8)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 23637-79-8(Hazardous Substances Data)
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23637-79-8 Usage
Uses
Used in Pharmaceutical Industry:17-Ethinyl-17-hydroxy-18-methylestra-5(10),9(11)-dien-3-one-3-ethylene ketal is used as an intermediate in the synthesis of Gestrinone (G368800), a steroidal antiestrogen and antiprogestogen. It is an analog of Norgestrienone and exhibits antigonadotropin properties, making it a valuable compound in the development of medications for hormonal imbalances and related conditions.
In the synthesis of Gestrinone, 17-Ethinyl-17-hydroxy-18-methylestra-5(10),9(11)-dien-3-one-3-ethylene ketal contributes to the formation of the final product's molecular structure, which is responsible for its therapeutic effects. Gestrinone is used to treat various conditions, including endometriosis, uterine fibroids, and certain types of cancer, such as breast and ovarian cancer. The compound's role in the synthesis of Gestrinone highlights its importance in the pharmaceutical industry and its potential applications in the development of new medications.
Check Digit Verification of cas no
The CAS Registry Mumber 23637-79-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,6,3 and 7 respectively; the second part has 2 digits, 7 and 9 respectively.Calculate Digit Verification of CAS Registry Number 23637-79:
(7*2)+(6*3)+(5*6)+(4*3)+(3*7)+(2*7)+(1*9)=118
118 % 10 = 8
So 23637-79-8 is a valid CAS Registry Number.
23637-79-8Upstream product
23637-79-8Downstream Products
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17-Ethinyl-17-hydroxy-18-methylestra-5(10),9(11)-dien-3-one-3-ethylene ketal
