236408-50-7

Basic information

• Product Name: (S)-p-chloro-α-methylstyrene oxide
• Synonyms: (S)-p-chloro-α-methylstyrene oxide
• CAS NO: 236408-50-7
• Molecular Weight: 168.623
• Mol File: 236408-50-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (S)-p-chloro-α-methylstyrene oxide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-p-chloro-α-methylstyrene oxide(236408-50-7)
• EPA Substance Registry System: (S)-p-chloro-α-methylstyrene oxide(236408-50-7)

Safety Data

• Hazardous Substances Data: 236408-50-7(Hazardous Substances Data)

Upstream product

• 1669-70-1 p-chloro-α-methylstyrene oxide 
• 99-91-2 para-chloroacetophenone 
• 1712-70-5 1-chloro-4-(1-methylethenyl)-benzene 
• 70775-39-2 dimethylsulfoxonium methylide 

Downstream Products

• 1146490-04-1 (2R)-2-(4-chlorophenyl)-2-methyloxetane 

Relevant articles and documents

Highly enantioselective epoxidation of olefins by H2O2 catalyzed by a non-heme Fe(ii) catalyst of a chiral tetradentate ligand

The chiral tetradentate N4-donor ligand, 1-methyl-2-({(S)-2-[(S)-1-(1-methylbenzimidazol-2-yl methyl)pyrrolidin-2-yl]pyrrolidin-1-yl}methyl) benzimidazole (S,S-PDBzL), based on a chiral dipyrrolidine backbone, has been synthesized and its corresponding Fe(ii) complex has been prepared and characterized. The X-ray structure of the complex reveals that the Fe(ii) ion is in a distorted octahedral coordination environment with two cis-oriented coordination sites occupied by (labile) triflate anions. The ability of the iron complex to catalyze asymmetric epoxidation reactions of olefins with H2O2 was investigated, using 2-cyclohexen-1-one, 2-cyclopenten-1-one, cis-β-methylstyrene, isophorone, chalcones and tetralones as substrates. Different carboxylic acids were used as additives to enhance yields and enantioselectivities, and 2-ethylhexanoic acid was found to give the best results. The catalysis results indicate that the Fe(ii) complex is capable of effecting comparatively high enantioselectivities (>80%) in the epoxidation reactions.

Resolution of 2,2-disubstituted epoxides via biocatalytic azidolysis

A practical procedure for the enzymatic resolution of 2-alkyl-2-aryl- disubstituted epoxides using the Codex HHDH P2E2 enzyme and sodium azide is reported. This method allowed the synthesis of novel regio-and enantioselective 1-azido-2-arylpropan-2-ols in

Catalytic asymmetric synthesis of 2,2-disubstituted oxetanes from ketones by using a one-pot sequential addition of sulfur ylide

(Chemical Equation Presented) Better the second time around: The title compounds were synthesized by using a one-pot double methylene transfer catalyzed by a heterobimetallic La/Li complex. Chiral amplification in the second step was the key to obtaining