2365-54-0Relevant academic research and scientific papers
Antibody catalyzed hydrolysis of a phosphotriester
Lavey, Brian J.,Janda, Kim D.
, p. 1523 - 1524 (1996)
An antibody (15C5) raised against N-oxide hapten 1 catalyzed the hydrolysis of phosphotriester 2, with a k(cat) of 2.65 x 10-3 min-1, K(m) of 87 μM, and displayed multiple turnovers.
Vitamin D3 cyclic phosphate and preparation method thereof
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Paragraph 0042; 0045; 0049; 0050; 0051; 0052; 0053-0055, (2018/04/02)
The invention provides vitamin D3 cyclic phosphate shown as a formula (1) and a preparation method thereof. The formula (1) is shown in the description, wherein R1 and R2 represent a hydrogen atom, C1to C5 alkyl, CH2C6H5, C6H5, NO2C6H4, NO2C6H4CH2, NO2 or
THIONUCLEOSIDE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION
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Paragraph 0534-0537, (2017/12/27)
Disclosed are a compound and a pharmaceutical composition that exhibit an excellent drug efficacy against a tumor, in particular a tumor which has acquired resistance to gemcitabine. Specifically, provided is a thionucleoside derivative represented by General Formula [1] (in the formula, R1 represents a hydroxyl group which may be protected, a C1-20 alkoxy group which may be substituted, or the like; R2 represents a C1-20 alkoxy group which may be substituted, a C3-8 cycloalkoxy group which may be substituted, or the like; and R3 represents a hydrogen atom or the like); or a salt thereof. Further, provided is a pharmaceutical composition containing such a thionucleoside derivative or a salt thereof.
