2366-61-2Relevant academic research and scientific papers
Semi-Industrial Fluorination of β-Keto Esters with SF 4: Safety vs Efficacy
Bugera, Maksym Y.,Khairulin, Andrii R.,Kliukovskyi, Denys V.,Ryabukhin, Sergey V.,Semenov, Sergey V.,Shevchenko, Valerii O.,Tarasenko, Karen V.,Trofymchuk, Serhii A.,Volochnyuk, Dmitriy M.
, p. 565 - 574 (2020/03/27)
The possibility of deoxofluorination of β-keto esters using SF 4 was investigated. The scope and limitation of the reaction were determined. The efficient method for the synthesis of β,β-difluorocarboxylic acids was elaborated based on the reaction. The set of mentioned acids, being the perspective building blocks for medicinal chemistry, were synthesized on multigram scale. The safety of SF 4 use was discussed. The described method does not improve upon the safety of using SF 4, but practical recommendations for working with the reagent are proposed. Despite the hazards of using toxic SF 4, a significant increase of efficacy in the synthesis of medicinal-chemistry-relevant building blocks, based on the reaction, in comparison with earlier described approaches is shown.
SERINE/THREONINE KINASE INHIBITORS
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Paragraph 00188, (2015/07/16)
Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such diseases, or associated pathological conditions are disclosed.
REACTION OF KETOCARBOXYLIC ESTERS WITH SULFUR TETRAFLUORIDE IN ANHYDROUS HYDROGEN FLUORIDE
Bloshchitsa, F. A.,Burmakov, A. I.,Kunshenko, B. V.,Alekseeva, L. A.,Bel'ferman, A. L.,et al.
, p. 1260 - 1263 (2007/10/02)
The reaction of ketocarboxylic esters with sulfur tetrafluoride in anhydrous hydrogen fluoride at 20 deg C gives good yields of difluorocarboxylic esters.Hydrolysis of the latter gave the corresponding carboxylic acids.
