236744-30-2

Upstream product

• 98-74-8 4-Nitrobenzenesulfonyl chloride 

Downstream Products

• 236744-34-6 (2S,3S)-3-Allyloxy-2-[(2S,3R)-4-benzyloxy-2-(3-benzyloxycarbonyl-propionylamino)-3-hydroxy-butyrylamino]-4-((2S,3R,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yl)-butyric acid ethyl ester 
• 236744-33-5 ethyl (2R,3S)-2-(tert-butyloxycarbonyl-amino)-3-allyloxy-4-(tri-O-benzyl-α-L-fucopyranosyl)-butanoate 
• 236744-32-4 ethyl (2R,3S)-2-(tert-butyloxycarbonyl-amino)-3-hydroxy-4-(tri-O-benzyl-α-L-fucopyranosyl)-butanoate 
• 236744-31-3 ethyl (2R,3S)-2-azido-3-hydroxy-4-(tri-O-benzyl-α-L-fucopyranosyl)-butanoate 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of aryl-substituted sialyl Lewis X mimetics prepared via cross-metathesis of C-fucopeptides

Several aryl substituted C-fucopeptides have been developed as sialyl Lewis X mimetics. Although the compounds have a much simpler structure compared to SLe(x), up to 3-times higher binding affinity toward E-selectin and >1000 times toward P-selectin was observed. Furthermore, a convenient strategy for generating a number of analogues from a SLe(x) mimetic template at a very late stage of the synthesis was introduced, using a ruthenium catalyzed cross olefin metathesis under benchtop conditions. Copyright (C) 1999 Elsevier Science Ltd.