2369-20-2

Basic information

• Product Name: Benzenamine, 3-fluoro-N-hydroxy-
• CAS NO: 2369-20-2
• Molecular Formula: C6H6FNO
• Molecular Weight: 127.118
• Mol File: 2369-20-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzenamine, 3-fluoro-N-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 3-fluoro-N-hydroxy-(2369-20-2)
• EPA Substance Registry System: Benzenamine, 3-fluoro-N-hydroxy-(2369-20-2)

Safety Data

• Hazardous Substances Data: 2369-20-2(Hazardous Substances Data)

Upstream product

• 402-67-5 3-fluoro-1-nitrobenzene 

Downstream Products

• 1629-17-0 N-(2-bromo-5-fluorophenyl)benzamide 
• 350-53-8 1-fluoro-3-nitrosobenzene 

Relevant articles and documents

Redox-Neutral Selenium-Catalysed Isomerisation of para-Hydroxamic Acids into para-Aminophenols

A selenium-catalysed para-hydroxylation of N-aryl-hydroxamic acids is reported. Mechanistically, the reaction comprises an N?O bond cleavage and consecutive selenium-induced [2,3]-rearrangement to deliver para-hydroxyaniline derivatives. The mechanism is studied through both 18O-crossover experiments as well as quantum chemical calculations. This redox-neutral transformation provides an unconventional synthetic approach to para-aminophenols.

Regioselective installation of fluorosulfate (-OSO2F) functionality into aromatic C(sp2)-H bonds for the construction of: Para-amino-arylfluorosulfates

The construction of para-amino-arylfluorosulfates was achieved through installation of fluorosulfate (-OSO2F) functionality into aromatic C(sp2)-H bonds by the reaction of N-arylhydroxylamine with sulfuryl fluoride (SO2Fs

TRIFLUOROMETHOXYLATION OF ARENES VIA INTRAMOLECULAR TRIFLUOROMETHOXY GROUP MIGRATION

The present invention provides a process of producing a trifluoromethoxylated aryl or trifluoromethoxylated heteroaryl having the structure: (I), wherein A is an aryl or heteroaryl, each with or without subsutitution; and R1 is -H, -(alkyl), -(alkenyl), -(alkynyl), -(aryl), -(heteroaryl), - (alkylaryl), - (alkylheteroaryl), -NH-(alkyl), -N(alkyl)2, -NH-(alkenyl), -NH-(alkynyl) -NH-(aryl), -NH-(heteroaryl), -O-(alkyl), -O-(alkenyl), -O-(alkynyl), -O-(aryl), -O-(heteroaryl), -S-(alkyl), -S- (alkenyl), -S-(alkynyl), -S-(aryl), or -S-(heteroaryl), comprising: (a) reacting a compound having the structure: (II), with a trifluoromethylating agent in the presence of a base in a first suitable solvent under conditions to produce a compound having the structure: (III); and (b) maintaining the compound produced in step (a) in a second suitable solvent under conditions sufficient to produce the trifluoromethoxylated aryl or trifluormethoxylated heteroaryl having the structure: (I).