237057-77-1

Basic information

• Product Name: (S)-N-benzyl-2-hydroxy-3-phenylpropionamide
• Synonyms: (S)-N-benzyl-2-hydroxy-3-phenylpropionamide
• CAS NO: 237057-77-1
• Molecular Weight: 255.316
• Mol File: 237057-77-1.mol

Chemical Properties

• CAS DataBase Reference: (S)-N-benzyl-2-hydroxy-3-phenylpropionamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-benzyl-2-hydroxy-3-phenylpropionamide(237057-77-1)
• EPA Substance Registry System: (S)-N-benzyl-2-hydroxy-3-phenylpropionamide(237057-77-1)

Safety Data

• Hazardous Substances Data: 237057-77-1(Hazardous Substances Data)

Upstream product

• 215593-50-3 acetic acid 1-benzylcarbamoyl-2-phenylethyl ester 
• 20312-36-1 L-3-phenyllactic acid 
• 100-46-9 benzylamine 
• 1009-67-2 2-methyl-3-phenylpropionic acid 
• 33173-31-8 (S)-3-phenyl-2-acetyloxypropionic acid 
• 122-78-1 phenylacetaldehyde 
• 88333-03-3 Benzyl isocyanide 

Downstream Products

• 946534-43-6 C₁₇H₁₉NO₃SO 
• 446253-67-4 (2R)-2-azido-N-benzyl-3-phenylpropionamide 
• 72244-52-1 (R)-N-benzyl 2-amino-3-phenylpropionamide 

Relevant articles and documents

Amidation of unactivated ester derivatives mediated by trifluoroethanol

A catalytic amidation protocol mediated by 2,2,2-trifluoroethanol has been developed, facilitating the condensation of unactivated esters and amines, furnishing both secondary and tertiary amides. The complete scope and limitations of the method are described, along with modified conditions for challenging substrates such as acyclic secondary amines and chiral esters with retention of chiral integrity.

PRODUCTION METHOD FOR HYDROXY-CARBOXYLIC ACID AMIDE COMPOUND, AND NOVEL ARYLBORONIC ACID COMPOUND

A method for production of hydroxycarboxylic acid amide compounds, comprising performing amide condensation between an α- or β-hydroxycarboxylic acid compound and an amine compound in the presence as a catalyst of an alkylboronic acid represented by R3B(OH)2 (wherein R3 is a primary alkyl group) or an arylboronic acid compound to produce a hydroxycarboxylic acid amide compound, the arylboronic acid compound being represented by Formula (1): (in Formula (1), -(CH2)nNR1R2 is bonded at an ortho position or a para position, n is 1 or 2, R1 is a tertiary alkyl group, R2 is a secondary or tertiary alkyl group, and -NR1R2 may be a ring).

Primary alkylboronic acids as highly active catalysts for the dehydrative amide condensation of α-hydroxycarboxylic acids

Primary alkylboronic acids such as methylboronic acid and butylboronic acid are highly active catalysts for the dehydrative amide condensation of α-hydroxycarboxylic acids. The catalytic activities of these primary alkylboronic acids are much higher than those of the previously reported arylboronic acids. The present method was easily applied to a large-scale synthesis, and 14 g of an amide was obtained in a single reaction.

Studies on the application of the Passerini reaction and enzymatic procedures to the synthesis of tripeptide mimetics

A new, efficient method for the multicomponent synthesis of tripeptide mimetics is presented. Simple, chemoenzymatic transformations of Passerini reaction products enable the introduction of varied amino acid moieties into the tripeptide scaffold, with co

Atropisomeric amides: Stereoselective enolate chemistry and enantioselective synthesis via a new SmI2-mediated reduction

The use of certain types of atropisomeric amides, incorporating an N-MEM-ortho-tert-bityariume group, for stereoselective reactions, has been explored. Enolate reactions of these systems are highly diastereocontrolled, and enantiomerically enriched starting materials can be obtained, starting from lactic acid, via a new SmI2 mediated reduction process.