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Usage

Uses

Used in Pharmaceutical Industry:
[4-(benzyloxy)benzyl]hydrazine hydrochloride is used as a building block for the synthesis of various organic compounds, particularly in the pharmaceutical industry. Its role in the synthesis process is crucial for creating a wide range of medications with diverse therapeutic applications.
Used in Anticancer Applications:
In the field of oncology, [4-(benzyloxy)benzyl]hydrazine hydrochloride is being investigated for its potential as an anticancer agent. Its hydrazine derivative nature allows it to be a promising candidate in the development of new cancer treatments, targeting various types of cancer cells and potentially improving patient outcomes.
Used in Chemical Research:
As a chemical compound with unique properties, [4-(benzyloxy)benzyl]hydrazine hydrochloride is also used in chemical research to study its reactivity, stability, and potential applications in various chemical reactions. This research can lead to the discovery of new compounds and materials with novel properties and applications.

Upstream product

• 836-42-0 4-benzyloxybenzyl chloride 

Downstream Products

• 380227-22-5 (4-hydroxybenzyl)hydrazine hydrochloride 

Relevant academic research and scientific papers

Structural insights into the substrate specificity of bacterial copper amine oxidase obtained by using irreversible inhibitors

Copper amine oxidases (CAOs) catalyse the oxidation of various aliphatic amines to the corresponding aldehydes, ammonia and hydrogen peroxide. Although CAOs from various organisms share a highly conserved active-site structure including a protein-derived cofactor, topa quinone (TPQ), their substrate specificities differ considerably. To obtain structural insights into the substrate specificity of a CAO from Arthrobacter globiformis (AGAO), we have determined the X-ray crystal structures of AGAO complexed with irreversible inhibitors that form covalent adducts with TPQ. Three hydrazine derivatives, benzylhydrazine (BHZ), 4-hydroxybenzylhydrazine (4-OH-BHZ) and phenylhydrazine (PHZ) formed predominantly a hydrazone adduct, which is structurally analogous to the substrate Schiff base of TPQ formed during the catalytic reaction. With BHZ and 4-OH-BHZ, but not with PHZ, the inhibitor aromatic ring is bound to a hydrophobic cavity near the active site in a well-defined conformation. Furthermore, the hydrogen atom on the hydrazone nitrogen is located closer to the catalytic base in the BHZ and 4-OH-BHZ adducts than in the PHZ adduct. These results correlate well with the reactivity of 2-phenylethylamine and tyramine as preferred substrates for AGAO and also explain why benzylamine is a poor substrate with markedly decreased rate constants for the steps of proton abstraction and the following hydrolysis. The Authors 2011. Published by Oxford University Press on behalf of the Japanese Biochemical Society. The Authors 2011. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved.