237075-81-9

Upstream product

• 237075-79-5 1-[7-(tert-butyl-dimethyl-silanyloxy)-8-fluoro-2-methoxy-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-5-fluoro-1H-pyrimidine-2,4-dione 
• 237075-78-4 5-Fluoro-1-((4aR,6R,7S,8R,8aR)-8-fluoro-7-hydroxy-2-methoxy-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl)-1H-pyrimidine-2,4-dione 
• 475573-02-5 5-fluoro-1-(2-O-t-butyldimethylsilyl-3-deoxy-3-fluoro-4,6-O-isopropylidene-β-D-glucopyranosyl)uracil 
• 475573-01-4 5-fluoro-1-(3-deoxy-3-fluoro-4,6-O-isopropylidene-β-D-glucopyranosyl)uracil 
• 237075-75-1 5-fluoro-1-(3-deoxy-3-fluoro-2,4,6-tri-O-acetyl-β-D-glucopyranosyl)uracol 
• 237075-76-2 1-(3'-deoxy-3'-fluoro-β-D-glucopyranosyl)5-fluorouracil 
• 76-83-5 trityl chloride 
• 237075-80-8 5-fluoro-1-(2-O-t-butyldimethylsilyl-3-deoxy-3-fluoro-β-D-glucopyranosyl)uracil 

Downstream Products

• 237075-82-0 5-fluoro-1-(4-O-acetyl-2-O-t-butyldimethylsilyl-3-deoxy-3-fluoro-6-O-trityl-β-D-glucopyranosyl)uracil 
• 237075-83-1 5-fluoro-1-(4-O-acetyl-3-deoxy-3-fluoro-6-O-trityl-β-D-glucopyranosyl)uracil 

Relevant academic research and scientific papers

5-Fluoro-1-(3,4-dideoxy-3-fluoro-6-0-trityl-beta-D-glycerohex-3-eno- pyranos-2-ulosyl (uracil): Anticancer agent

1,2:5,6-Di-0-isopropylidene glucofuranose on mild oxidation, reduction, fluorination and deisopropylidenation followed by acetylation gave peracetylated 3-deoxy-3-fluoro-alpha-D-glucopyranose. This was coupled with silylated 5 fluorouracil. The nucleoside

Unsaturated fluoroketonucleosides as anticancer agents: the synthesis and biological activity of 5-fluoro-1-(3,4-di-deoxy-3-fluoro-6-O-trityl-beta-d-glycero-hex-3-eno-pyranos-2- ulosyl) uracil.

Direct oxidation of 5-fluoro-1-(4-O-acetyl-3-deoxy-3-fluoro-6-O-trityl-beta-D-glucopyranosyl) uracil 9 led to the title compound 10 after a beta-elimination reaction. The formation of the hydrate of ketone 10 due to the highly electronegative fluorine ato