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(2S)-2-[(3S)-3,4-Dihydro-3α-carboxy-5,6,7-trihydroxy-1-oxo-1H-2-benzopyran-4β-yl]butanedioic acid, also known as Chebulic acid (CA), is a phenolic compound derived from the ripe fruits of Terminalia chebula. It is a component of transformed ellagitannins such as chebulagic acid or chebulinic acid and has an isomer, neochebulic acid. Chebulic acid is recognized for its potent antioxidant properties and potential therapeutic applications.

23725-05-5

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23725-05-5 Usage

Uses

Used in Pharmaceutical Applications:
Chebulic acid is used as a therapeutic agent for treating asthma and other respiratory conditions. Its potent antioxidant properties make it a valuable resource in combating oxidative stress and related health issues.
Used in Antioxidant Applications:
Chebulic acid is utilized as a potent antioxidant, protecting the body from the harmful effects of free radicals and reducing the risk of cardiopulmonary vascular dysfunction, particularly in individuals exposed to ambient urban particulate matter (UPM).
Used in Anticancer Applications:
While not explicitly mentioned in the provided materials, given the structural similarity to gallotannin and its potent antioxidant properties, it is plausible that Chebulic acid could also be investigated for potential anticancer applications, similar to gallotannin's use in modulating oncological signaling pathways and enhancing the efficacy of conventional chemotherapeutic drugs.
Used in Drug Delivery Systems:
As with gallotannin, the development of novel drug delivery systems for Chebulic acid could be explored to enhance its applications and efficacy against various health conditions, including cancer cells. Utilizing organic and metallic nanoparticles as carriers for Chebulic acid delivery could improve its bioavailability and therapeutic outcomes.

Bioactivities

Chebulinic acid showed many bioactivities including inhibition of cancer cell growth, inhibiting the contractile responses of cardiovascular muscles, anti-fungal, anti-bacterial activities etc. In-vitro anti-cancer activity of Chebulinic acid on Colon adenocarcinoma HT-29 cancer cell lines by using MTT cell growth inhibition assay was stuied. The maximum percentage inhibition of cancer cell lines for Chebulinic acid was found to be 41.2% at a dose of 200μg/ml. Chebulinic acid extraction from Terminalia chebula plays a vital role in medicine, biotechnology and various pharmacological activities.

Check Digit Verification of cas no

The CAS Registry Mumber 23725-05-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,7,2 and 5 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 23725-05:
(7*2)+(6*3)+(5*7)+(4*2)+(3*5)+(2*0)+(1*5)=95
95 % 10 = 5
So 23725-05-5 is a valid CAS Registry Number.

23725-05-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S)-2-[(3S,4S)-3-carboxy-5,6,7-trihydroxy-1-oxo-3,4-dihydroisochromen-4-yl]butanedioic acid

1.2 Other means of identification

Product number -
Other names (S)-2-((3S,4S)-3-carboxy-5,6,7-trihydroxy-1-oxoisochroman-4-yl)succinic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:23725-05-5 SDS

23725-05-5Upstream product

23725-05-5Downstream Products

23725-05-5Relevant academic research and scientific papers

Hydrolyzable tannins from the fruits of Terminalia chebula Retz and their α-glucosidase inhibitory activities

Lee, Dong Young,Kim, Hyun Woo,Yang, Heejung,Sung, Sang Hyun

, p. 109 - 116 (2017/03/27)

Nine hydrolyzable tannins, including three previously unknown and six artifacts, were isolated, together with thirty-nine known ones, from the fruits of Terminalia chebula Retz. (Combretaceae). They were identified as 1,2,3-tri-O-galloyl-6-O-cinnamoyl-β-D

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