23730-34-9Relevant academic research and scientific papers
Solvolysis of 2-(Trifluoromethyl)-2-propyl Trifluoromethanesulfonate. Solvent, Salt, and β-Deuterium Isotope Effects. Sucstituent Effect of a Strongly Deactivating Group and Rate-Limiting Solvent-Assisted Elimination
Jansen, Michael P.,Koshy, Kalavelil M.,Mangru, Nevindra N.,Tidwell, Thomas T.
, p. 3863 - 3867 (1981)
Solvolysis rates of 2-(trifluoromethyl)-2-propyl trifluoromethanesulfonate (2c) in a variety of solvents did not show a correlation with rates for 2-adamantyl tosylate in the same solvents.The effect of added salts on the rates of 2c and 2-propyl tosylate in 80percent EtOH was very similar, with significant rate increases for nucleophilic/basic salts.Methyl CD3 isotope effects on the rate of 2c in three solvents showed average values k(d0)/k(d3) = 1.78 and k(d0)/k(d6) = 3.80.The initial observed product from 2c was CF3C(CH3)=CH2 (4) in all cases.The rate ratio k(i-PrOTf)/k(2c) ranges from a high of 4 x 106 in TFA to a low of 1.5 x 104 in EtOH and shows a high degree of destabilization of a cationic transition state by the CF3 group.The results are interpreted in terms of rate-limiting solvent or salt attack on an intimate ion pair formed from 2c.The observed average product ratio CF3C(CD3)=CH2/CF3C(CH3)=CD2 of 1.9 from 2c-d3 in CF3CO2D, HFIP, and CD3CO2D is consistent with this conclusion.
Method for preparing 2-bromo-1, 1, 1-trifluoro-2-methylpropane
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Paragraph 0006; 0025, (2021/06/13)
The invention discloses a method for preparing 2-bromine-1, 1, 1-trifluoro-2-methyl propane, which comprises the following steps of: adding 2-bromine-1, 1, 1-trifluoro-2-methyl propane into a reaction kettle; and by taking 1, 1, 1-trifluoro-2-methyl-2-pro
Synthesis method of 3,3,3-trifluoro-2,2-dimethylpropionic acid
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Paragraph 0010, (2019/01/23)
The invention relates to a synthesis method of 3,3,3-trifluoro-2,2-dimethylpropionic acid. The synthesis method comprises the following steps: adding 2-trifluoromethyl-2-propanol and acetonitrile intoa container, cooling and adding sodium hydride, carryin
