237385-94-3Relevant academic research and scientific papers
Structure-Based design, synthesis and SAR of a novel series of thiopheneamidine urokinase plasminogen activator inhibitors
Subasinghe, Nalin L.,Illig, Carl,Hoffman, James,Rudolph,Wilson, Kenneth J.,Soll, Richard,Randle, Troy,Green, David,Lewandowski, Frank,Zhang, Marie,Bone, Roger,Spurlino, John,DesJarlais, Renee,Deckman, Ingrid,Molloy, Christopher J.,Manthey, Carl,Zhou, Zhau,Sharp, Celia,Maguire, Diane,Crysler, Carl,Grasberger, Bruce
, p. 1379 - 1382 (2007/10/03)
The serine protease urokinase plasminogen activator (uPA) is thought to play a central role in tumor metastasis and angiogenesis. Molecular modeling studies suggest that 5-thiomethylthiopheneamidine inhibits uPA by binding at the S1 pocket of the active site. Further structure based elaboration of this residue resulted in a novel class of potent and selective inhibitors of uPA.
