23740-98-9Relevant academic research and scientific papers
Synthesis of 3-substituted 3H-indol-3-ols by the reaction of 2-isocyanophenyl ketones with Grignard reagents
Kobayashi, Kazuhiro,Okamura, Yuta,Fukamachi, Shuhei,Konishi, Hisatoshi
experimental part, p. 7961 - 7964 (2010/10/19)
A facile method for the synthesis of 3-substituted 3H-indol-3-ols has been developed. Thus, 2-isocyanophenyl ketones are allowed to react with various Grignard reagents to give the corresponding desired indolol derivatives in generally fair to good yields. The formation of 3-aryl-2,3-dimethylindolin-3-ols by the reaction of 2-isocyanobenzophenones with 2 M amounts of methylmagnesium bromide is also reported.
Study of the addition of Grignard reagents to 2-aryl-3H-indol-3-ones
Liu, Yahua,McWhorter Jr., William W.
, p. 2618 - 2622 (2007/10/03)
Grignard reagents are added to the carbonyl group of 2-aryl-3H-indol-3-ones to generate 3-alkyl-(or phenyl)-2-aryl-3H-indol-3-ols, which are in turn rearranged to yield 2-alkyl(or phenyl)-2-aryl-1,2-dihydro-3H-indol-3-ones.
Heterocyclic 8?-Systems, 16 - Elimination Reactions of 2-Alkoxy-3-hydroxyindolines
Beitzke, Bernhard,Schmidt, Richard R.
, p. 1726 - 1731 (2007/10/02)
Thermolysis of 2-ethoxy-3-hydroxyindolines 1a - f affords oxindoles 3a - f as main products and the corresponding 3-indolinones 2a - f as by-products.The reaction course via indole 2,3-oxide intermediates is discussed.For this reason rearrangement reactio
Heterocyclic 8?-Systems, 15. Investigations on Indole 2,3-Oxides: Sythesis of 3-Hydroxyindoles via Intramolecular Wittig-Rearrangement of 1,2-Dihydro-4H-3,1-benzoxazines
Schmidt, Richard R.,Beitzke, Bernhard
, p. 2115 - 2135 (2007/10/02)
Investigations to trap indole 2,3-oxides 11 by base catalyzed ring contraction of 4H-3,1-benzoxazines 3 led in the system KNH2/NH3 to 3-hydroxy-3H-indoles 7.The N-methylbenzoxazinium salts 15, obtained from 3 and FSO3CH3, yielded with ethoxide under kinet
