237403-65-5

Upstream product

• 3047-32-3 3-ethyl-3-(hydroxymethyl)oxetane 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 477949-72-7 4-(3-ethyloxetane-3-ylmethoxy)-benzoic acid 
• 1360568-86-0 (2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-((3-ethyloxetan-3-yl)methoxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol 
• 1360568-85-9 3-((4-(5-bromo-2-chlorobenzyl)phenoxy)methyl)-3-ethyloxetane 
• 1160656-35-8 5-bromo-2-(3-ethyl-oxetan-3-ylmethoxy)-benzaldehyde 
• 1047646-47-8 C₄₀H₅₂O₆ 
• 473995-23-2 C₃₈H₄₈O₆ 
• 929621-15-8 C₄₂H₅₄O₆ 

Relevant academic research and scientific papers

5-OXA-2-AZASPIRO[3.4]OCTANE DERIVATIVES AS M4 AGONISTS

Provided herein are compounds according to Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, and R7 are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) as well as the use of such compounds as M4 receptor agonists.

TRIOXETANE ETHER COMPOUND

PROBLEM TO BE SOLVED: To provide a novel oxetane compound capable of providing a cured resin excellent in heat resistance and flexibility. SOLUTION: There is provided a trioxetane ether compound represented by the general formula (1) in the figure. (In th

COMPOUND APPLICABLE TO PHOTOALIGNMENT METHOD AND ITS PHOTOSENSITIVE POLYMER

PURPOSE: A photosensitive polymer prepared by polymerizing a compound which is proper for photoalignment is provided to prevent static electricity and to manufacture liquid crystal alignment film with high optical uniformity. CONSTITUTION: A compound which is proper to photoalignment is denoted by chemical formula 1. A photosensitive polymer is used by polymerizing the compound of chemical formula 1. A liquid crystal alignment film is manufactured using the photoalignment agent. A liquid crystal display device is manufactured using the photoalignment agent.

ITRACONAZOLE ANALOGS AND USE THEREOF

Provided herein are Itraconazole analogs. Also provided herein are methods of inhibition of Hedgehog pathway, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, angiogenesis and treatment of disease with Itraconazole analogs.

CYCLOALKYL METHOXYBENZYL PHENYL PYRAN DERIVATIVES AS SODIUM DEPENDENT GLUCOSE CO TRANSPORTER (SGLT2) INHIBITORS

The invention relates to the cycloalkyl methoxybenzyl phenyl pyran derivatives as Sodium dependent glucose co transporter (SGLT) inhibitors, particularly SGLT2 and method of treating diseases, conditions and/or disorders inhibited by SGLT2 with them, and processes for preparing them.

Itraconazole Side Chain Analogues: Structure-Activity Relationship Studies for Inhibition of Endothelial Cell Proliferation, Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Glycosylation, and Hedgehog Signaling

Itraconazole is an antifungal drug that was recently found to possess potent antiangiogenic activity and anti-hedgehog (Hh) pathway activity. To search for analogues of itraconazole with greater potency and to understand the structure-activity relationship in both antiangiogenic and Hh targeting activity, 25 itraconazole side chain analogues were synthesized and assayed for inhibition of endothelial cell proliferation and Gli1 transcription in a medulloblastoma (MB) culture. Through this analysis, we have identified analogues with increased potency for inhibiting endothelial cell proliferation and the Hh pathway, as well as VEGFR2 glycosylation that was recently found to be inhibited by itraconazole. An SAR analysis of these activities revealed that potent activity of the analogues against VEGFR2 glycosylation was generally driven by side chains of at least four carbons in composition with branching at the α or β position. SAR trends for targeting the Hh pathway were divergent from those related to HUVEC proliferation or VEGFR2 glycosylation. These results also suggest that modification of the sec-butyl side chain can lead to enhancement of the biological activity of itraconazole.

3-ETHYLOXETHANE COMPOUND HAVING HYDROXYL GROUP AND METHOD FOR PRODUCING THE SAME

Disclosed is a 3-ethyloxethane compound having a hydroxyl group which is represented by the following general formula (1). (1) (In the formula, A represents an alkylene group having 3-5 carbon atoms which may have an ether bond or an alkylene group having

SPIROINDOLINONE DERIVATIVES

There are provided compounds of the formula and pharmaceutically acceptable salts and esters thereof wherein W, V, X, Y, A, R and R' are as described herein. The compounds are useful as anticancer agents.

Trisoxetane compound, process for producing the same and optical waveguide using the same

The present invention relates to a trisoxetane compound represented by the following formula (1): wherein each of R1 and R3's represents a hydrogen atom or an alkyl group having 1 to 6 carbon atom(s); R2 represents a dival

Trisoxetane compound, process for producing the same, and opitcal waveguide using the same

The present invention relates to a trisoxetane compound represented by the following formula (1): wherein each of R1 and R3's represents a hydrogen atom or an alkyl group having 1 to 6 carbon atom(s); R2 represents a dival