237421-53-3Relevant articles and documents
A Stereoselective Synthesis of the ACE Inhibitor Trandolapril
Chiha, Slim,Spilles, Matthias,Neud?rfl, J?rg-Martin,Schmalz, Hans-Günther
, p. 813 - 816 (2019)
A conceptually novel and stereoselective synthesis of the enantiopure octahydroindole building block and its conversion into the ACE inhibitor trandolapril was achieved. Key steps include the α-allylation of a protected l -pyroglutamic acid derivative, a highly diastereoselective Hosomi-Sakurai reaction and a Ru-catalyzed ring-closing metathesis of a 4,5-diallylated proline. This way, the synthesis of trandolapril was efficiently achieved in 25% overall yield (12 steps).
Versatile synthesis of inhibitors of late enzymes in the bacterial pathway to lysine
Steger, Matthias,Young, Douglas W.
, p. 7935 - 7956 (2007/10/03)
Modification of our 'ring switching' reaction has allowed us to develop a versatile synthesis of potential inhibitors of the late enzymes in the bacterial pathway to lysine. The methodology is applicable to solid phase combinatorial synthesis.