237424-24-7Relevant academic research and scientific papers
Synthesis, characterization and cytotoxicity of some palladium(II), platinum(II), rhodium(I) and iridium(I) complexes of ferrocenylpyridine and related ligands. Crystal and molecular structure of trans-dichlorobis(3-ferrocenylpyridine)palladium(II)
Rajput, Jaisheila,Moss, John R.,Hutton, Alan T.,Hendricks, Denver T.,Arendse, Catherine E.,Imrie, Christopher
, p. 1553 - 1568 (2007/10/03)
The preparation of a series of ferrocenyl nitrogen donor ligands including ferrocenylpyridines, ferrocenylphenylpyridines and 1,1′-di(2-pyridyl)ferrocene is described. Coordination studies of the substituted pyridines (L) were carried out with platinum, palladium, rhodium and iridium. This resulted in the preparation of the following types of complexes: [MCl(CO)2(L)] and [M(cod)(L)2]ClO4 where M=Rh or Ir, cod=1,5-cyclooctadiene; [M′Cl2(L 2] where M′=Pt or Pd. The X-ray crystal structure of trans -dichlorobis(3-ferrocenylpyridine)palladium was obtained. The complexes were screened for activity against two human cancer cell lines. At least two of the complexes displayed growth inhibition similar to that of the widely used chemotherapeutic agent, cis platin.
Coupling of aryl halides with aryl boronic acids with P(C6H5)(2-C6H4Cl)2 as the supporting ligand
Pramick, Michelle R.,Rosemeier, Sara M.,Beranek, Maryann T.,Nickse, Stephanie B.,Stone, Joshua J.,Stockland Jr., Robert A.,Baldwin, Steven M.,Kastner, Margaret E.
, p. 523 - 528 (2008/10/08)
The chlorinated triarylphosphine P(C6H5)(2-C6H4Cl)2 (1) has been used as a supporting ligand in the Suzuki-Miyaura coupling of aryl boronic acids with aryl halides. Aryl bromides without ortho substituents were successfully coupled at room temperature, while reactions involving sterically hindered aryl bromides required slight heating (70°C). Electron-deficient aryl chlorides were also successfully coupled with heating (90°C). Key reaction parameters such as order of addition, choice of mineral base, solvent volume, temperature, 1/Pd ratio, as well as electronic and steric variation of the aryl halide have been investigated and are reported.
