237429-71-9

Upstream product

• 1575-37-7 4-Bromo-benzene-1,2-diamine 
• 875-51-4 4-Bromo-2-nitroaniline 
• 237429-70-8 5-bromo-2-(3,4-dinitrophenyl)benzimidazole 

Relevant academic research and scientific papers

Topoisomerase I inhibition and cytotoxicity of 5-bromo- and 5-phenylterbenzimidazoles

Topoisomerase I is an enzyme that is essential for maintaining the three-dimensional structure of DNA during the processes of transcription, translation and mitosis. With the introduction of new clinical agents that are effective in poisoning topoisomeras

Heterocyclic topoisomerase poisons

The invention provides a topoisomerase poison of formula I: wherein R1-R8 have any of the meanings defined in the specification, or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, and therapeutic methods comprising administering a compound of formula I or a salt thereof.