237435-27-7

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 3-amino-5-phenyl-1H-pyrrole-2-carboxylate is used as an inhibitor of interleukin-1β-converting enzyme (ICE) for its anti-inflammatory properties. By inhibiting ICE, it can help regulate the immune response and potentially treat conditions associated with excessive inflammation.
Used in Research Applications:
In the field of scientific research, ethyl 3-amino-5-phenyl-1H-pyrrole-2-carboxylate serves as a valuable compound for studying the mechanisms of inflammation and the role of interleukin-1β in various diseases. Its use as an ICE inhibitor can provide insights into the development of new therapeutic strategies for inflammatory disorders.
Used in Drug Development:
Ethyl 3-amino-5-phenyl-1H-pyrrole-2-carboxylate can be utilized in the development of new drugs targeting inflammatory conditions. Its ICE inhibitory activity makes it a promising candidate for the creation of novel pharmaceuticals that can help manage and treat a range of inflammatory diseases, including autoimmune disorders and chronic inflammatory conditions.

Upstream product

• 13433-00-6 diethyl aminomalonate hydrochloride 
• 237435-26-6 2-cyano-1-phenylvinyl-4-methylbenzenesulfonate 
• 614-16-4 Benzoylacetonitrile 

Downstream Products

• 34771-39-6 6-phenylpyrrolo[3,2-d]pyrimidine-2,4-diol 
• 237435-70-0 6-phenyl-2-propylpyrrolo[3,2-d]pyrimidin-4-ol 
• 237435-34-6 2-cyclopropyl-6-phenylpyrrolo[3,2-d]pyrimidine-4-ol 
• 313950-09-3 tert-butyl 2-aza-3-[(tert-butoxy)carbonylamino]-3-{[2-(ethoxycarbonyl)-5-phenylpyrrol-3-yl]amino}prop-2-enoate 
• 237435-32-4 2-ethyl-6-phenylpyrrolo[3,2-d]pyrimidine-4-ol 
• 850145-22-1 N-(3-chloropropyl)-N'-[3-(2-ethoxycarbonyl-5-phenyl)-1H-pyrrolyl]urea 
• 237435-53-9 6-phenyl-2-(trifluoromethyl)pyrrolo[3,2-d]pyrimidine-4-ol 
• 313950-09-3 tert-butyl 2-aza-3-[(tert-butoxy)carbonylamino]-3-{[2-(ethoxycarbonyl)-5-phenylpyrrol-3-yl]amino}prop-2-enoate 
• 237434-56-9 6-phenyl-4-piperidylpyrrolo[3,2-d]pyrimidin-2-ylamine 
• 237435-81-3 2-chloro-6-phenyl-4-piperidylpyrrolo[3,2-d]pyrimidine 
• 1026309-39-6 methanesulfonic acid 2-methylsulfanyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl ester 

Relevant academic research and scientific papers

Compounds and methods which modulate feeding behavior and related diseases

There are provided compounds, compositions and methods of use thereof in the modulation of feeding behavior, obesity, diabetes, cancer (tumor), inflammatory disorders, depression, stress related disorders, Alzheimer's disease and other disease conditions.

Structure-activity relationships of a series of pyrrolo[3,2-d]pyrimidine derivatives and related compounds as neuropeptide Y5 receptor antagonists

Neuropeptide Y (NPY) has been shown to play an important role in the regulation of food intake and energy balance. Pharmacological data suggests that the Y5 receptor subtype contributes to the effects of NPY on appetite, and therefore a Y5 antagonist might be a useful therapeutic agent for the treatment of obesity. In attempts to identify potential Y5 antagonists, a series of pyrrolo[3,2-d]pyrimidine derivatives was prepared and evaluated for their ability to bind to Y5 receptors in vitro. We report here the synthesis and initial structure-activity relationship investigations for this class of compounds. The target compounds were prepared by a variety of synthetic routes designed to modify both the substitution and the heterocyclic core of the pyrrolo[3,2-d]pyrimidine lead 1. In addition to identifying several potent Y5 antagonists for evaluation as potential antiobesity agents, a pharmacophore model for the human Y5 receptor is presented.