2374958-89-9 Usage
Uses
Used in Asymmetric Catalysis:
(4S,4'S)-4,4'-di((S)-sec-butyl)-4,4',5,5'-tetrahydro-2,2'-bioxazole is utilized as a ligand in asymmetric catalysis for its ability to facilitate stereocontrolled organic synthesis. Its chiral nature allows for the development of new catalysts that can selectively promote specific reactions, leading to the formation of desired enantiomers in chemical reactions.
Used in Coordination Chemistry:
In coordination chemistry, (4S,4'S)-4,4'-di((S)-sec-butyl)-4,4',5,5'-tetrahydro-2,2'-bioxazole serves as a ligand, contributing to the formation of metal complexes with unique properties and reactivity. This application is valuable for the advancement of homogeneous catalysis and the design of new catalysts for various chemical transformations.
Used in Stereocontrolled Organic Synthesis:
(4S,4'S)-4,4'-di((S)-sec-butyl)-4,4',5,5'-tetrahydro-2,2'-bioxazole is employed as a chiral building block in stereocontrolled organic synthesis, enabling the creation of complex molecules with specific stereochemistry. Its unique structure and properties make it a valuable tool for the synthesis of biologically active compounds and pharmaceuticals with desired chiral configurations.
Check Digit Verification of cas no
The CAS Registry Mumber 2374958-89-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 2,3,7,4,9,5 and 8 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 2374958-89:
(9*2)+(8*3)+(7*7)+(6*4)+(5*9)+(4*5)+(3*8)+(2*8)+(1*9)=229
229 % 10 = 9
So 2374958-89-9 is a valid CAS Registry Number.
2374958-89-9Relevant articles and documents
Asymmetric Ni-Catalyzed Radical Relayed Reductive Coupling
García-Domínguez, Andrés,Merino, Estíbaliz,Nevado, Cristina,Shu, Wei,Wei, Xiaofeng
, p. 13515 - 13522 (2020)
Alkene dicarbofunctionalizations enable the streamlined construction of aliphatic structures and have thus been the subject of intense research efforts. Despite significant progress, catalytic asymmetric variants remain scarce. Inspired by the advantages of reductive cross-coupling approaches, we present here a highly efficient asymmetric intermolecular Ni-catalyzed reductive dicarbofunctionalization of alkenes. Two distinct readily available electrophiles, namely, Csp2- and Csp3-halides, are added simultaneously across a variety of olefins (vinyl amides, vinyl boranes, vinyl phosphonates) at room temperature in a highly regio- and enantioselective manner. The reaction, devoid of sensitive organometallic reagents, takes advantage of an in situ generated chiral alkyl Ni(III)-intermediate to ensure a stereodefined outcome in the Csp3-Csp2 bond-forming reaction. An (l)-(+)-isoleucine chiral bisoxazoline ligand and the presence of coordinating sites on the alkene are key for the successful outcome in these asymmetric radical relayed reductive couplings (ARRRCs). Further, multiple transformations of the chiral amides obtained in this process showcase the potential of this new methodology for the straightforward assembly of chiral building blocks such as primary and secondary amines and oxazolines, highlighting its synthetic utility.
