23758-34-1

Basic information

• Product Name: 2-(3H-imidazol-4-yl)ethanamine hydrochloride
• Synonyms: 2-(3H-imidazol-4-yl)ethanamine hydrochloride
• CAS NO: 23758-34-1
• Molecular Formula: C₅H₉N₃*2ClH
• Molecular Weight: 0
• Mol File: 23758-34-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 331°Cat760mmHg
• Flash Point: 180.3°C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: 2-(3H-imidazol-4-yl)ethanamine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3H-imidazol-4-yl)ethanamine hydrochloride(23758-34-1)
• EPA Substance Registry System: 2-(3H-imidazol-4-yl)ethanamine hydrochloride(23758-34-1)

Safety Data

• Hazardous Substances Data: 23758-34-1(Hazardous Substances Data)

Usage

Structure

Imidazole ring, ethylamine chain These are the two main components of the compound's structure, with an imidazole ring and an ethylamine chain connected together.

Physical form

White crystalline powder This describes the appearance of the compound, which is a white, crystalline solid.

Solubility

Soluble in water This indicates that the compound can dissolve in water, which is important for its use as a pharmaceutical agent.

Uses

Pharmaceutical agent for treatment of various medical conditions, including gastric acid secretion, cardiovascular disorders, and as a central nervous system stimulant. This lists some of the main uses of the compound, which are primarily in the medical field.

Potential uses

Treatment of cancer and other diseases This indicates that the compound is being studied for its potential use in treating a range of other diseases, including cancer.

Upstream product

• 71-00-1 L-histidine 
• 51-45-6 histamine 
• 71-00-1 L-histidine 

Downstream Products

• 93366-39-3 N-<2-(imidazol-4-yl)ethyl>succinimide 
• 913510-33-5 N-<ω-(benzyloxyamino)hexanoyl>histamine 
• 878022-24-3 3-hydroxy-2-[2-(3H-imidazol-4-yl)ethyl]-3-phenyl-2,3-dihydroisoindol-1-one 
• 7271-14-9 [2-(3H-imidazol-4-yl)-ethyl]-(4-methoxy-benzylidene)-amine 
• 74058-75-6 N^α-(benzyloxycarbonyl)histamine 
• 83001-62-1 4-(2-(salicylideneamino)ethyl)imidazole 
• 98870-64-5 tert-butyl 2-(1H-imidazol-5-yl)ethylcarbamate 
• 151322-48-4 N⁶-benzoyl-5'-O-(4,4'-dimethoxytrityl)-8-[2-(imidazol-4-yl)ethylamino]-2'-deoxyadenosine 
• 5959-80-8 2-(2-(1H-imidazol-4-yl)ethyl)isoindoline-1,3-dione 
• 4875-50-7 4-(3,4,5-trimethoxyphenyl)-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine 
• 46964-25-4 4-(3,4-dimethoxyphenyl)-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine 

Relevant articles and documents

Synthesis method of high-purity histamine dihydrochloride

The invention discloses a synthesis method of high-purity histamine dihydrochloride, and belongs to the technical field of organic synthesis. The method comprises the steps: in a solvent A, carrying out a decarboxylation reactionon L-histidine at the temperature of 110-150 DEG C under the effect of a composite decarboxylation catalyst, and carrying out filtering after the reaction is completed, wherein the composite decarboxylation catalyst is composed of a main catalyst and an auxiliary catalyst, the main catalyst is selected from sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, pyridine, 4-methylpyridine, aniline, 4-methylaniline, ,N,N-dimethylaniline and N, N-dimethylformamide, and the auxiliary catalyst is one selected from benzophenone, acetophenone, benzophenone and p-methyl acetophenone; carrying out reduced pressure distillation on a filtrate, adding water into residues, and adjusting the pH value to 5-6 by using hydrochloric acid to obtain an aqueous solution; extracting the aqueous solution at least once by using an extracting agent to remove impurities; and evaporating to remove water in the aqueous solution, pulping with a solvent B, filtering and drying to obtain the product.

Synthetic method of histamine dichloride

The invention discloses a synthetic method of histamine dichloride, and belongs to the field of drug synthesis. The synthetic method comprises the following steps: preparing a cyano methylimidazole intermediate through oxidization of TCCA (Trichloroisocyanuric Acid) under an alkaline condition by taking L-histidine as an original raw material, and then preparing medicinal histamine dichloride through catalytic hydrogenation and one-step salifying process. In the histamine dichloride compounded through the synthetic method, the content of related substances is less than 0.5 percent, the content of a single impurity is less than 0.1 percent, and the histamine dichloride accords with medicinal level. A reagent adopted by the technology is cheap and of low-toxicity, the reaction is safe and reliable, an alcohol solvent can be recycled, after-treatment operation is simple and convenient, and the technology is environment-friendly and is beneficial for large-scale industrial production.