23771-98-4

Upstream product

• 775-16-6 N-benzyl-3-pyrrolidinone 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 1210965-45-9 1-benzyl-3-phenyl-3-(trimethylsilyloxy)pyrrolidine 
• 124563-09-3 (±)-1-benzyl-3-phenyl-pyrrolidin-3-amine 

Relevant academic research and scientific papers

3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Synthesis of 3-substituted 3-(trimethylsiloxy)pyrrolidines from β-aminoketones and lithium trimethylsilyldiazomethane

Lithium trimethylsilyldiazomethane reacted with N-benzyl-β-aminoketones at -78 °C in THF to give 3-substituted 1-benzyl-3-(trimethylsiloxy)pyrrolidines in moderate to good yields.