237765-25-2Relevant academic research and scientific papers
Copper(0) Nanoparticles in Click Chemistry: Synthesis of 3,5-Disubstituted Isoxazoles
Vishwanatha,Sureshbabu, Vommina V.
, p. 1823 - 1833 (2015/02/19)
An efficient procedure for the synthesis of 3,5-disubstituted isoxazoles via [3+2] cycloaddition reaction of in situ generated nitrile oxides with acetylenes employing readily preparable copper(0) nanoparticles is described. A variety of in situ generated
A facile one-pot synthesis of Nα-urethane protected 3-amino alkyl isoxazole-5-carboxylic acids and their utility for the preparation of isoxazole-linked peptidomimetics
Chennakrishnareddy,Vasantha,Narendra,Sureshbabu, Vommina V.
experimental part, p. 185 - 191 (2012/06/01)
Cu(I) catalyzed [3+2] cycloaddition of in situ generated N α-Fmoc/Boc/Z-protected amino alkyl nitrile oxide with propiolic acid has led to a new class of 3,5-disubstituted isoxazole-bearing amino acid derivatives. The click chemistry protocol described herein is efficient in furnishing the isoxazole embedded amino acids. These unnatural synthons were subjected to chain extension on N- as well as C-termini to obtain 3,5-disubstituted isoxazole bearing di and tripeptidomimetics. Springer Science+Business Media, LLC 2011.
A second-generation cycloaddition route to 5-substituted 3-acyltetramic acids
Jones, Raymond C. F.,Dawson, Claire E.,O'Mahony, Mary J.
, p. 873 - 876 (2007/10/03)
The 1,3-dipolar cycloaddition of α-aminonitrile oxides, formed from α- amino-acids, to enamines of β-ketoesters affords 3-(1-aminoalkyl)isoxazole- 4-carboxylic esters that are convened via pyrrolo[3,4-c]isoxazol-4-ones into 5-substituted 3-acetyltetramic
