23785-19-5

Usage

Chemical Family

2-(Iodomethyl)-1,4-benzodioxan belongs to the dioxane family.

Molecular Weight

The molecular weight of 2-(Iodomethyl)-1,4-benzodioxan is 284.08 g/mol.

Physical Appearance

2-(Iodomethyl)-1,4-benzodioxan is a white crystalline solid.

Use in Chemistry

2-(Iodomethyl)-1,4-benzodioxan is often used in organic and medicinal chemistry as a reagent or intermediate in the synthesis of various pharmaceuticals and other organic compounds.

Iodine Atom

The iodine atom in the molecule makes it a useful precursor for the synthesis of iodinated organic compounds.

Benzodioxane Moiety

The benzodioxane moiety in the structure contributes to its aromatic and functional group properties.

Building Block

2-(Iodomethyl)-1,4-benzodioxan is an important building block in organic synthesis.

Versatility

2-(Iodomethyl)-1,4-benzodioxan is a versatile chemical that finds various applications in research and industry.

InChI:InChI=1/C9H9IO2/c10-5-7-6-11-8-3-1-2-4-9(8)12-7/h1-4,7H,5-6H2

Upstream product

• 3663-82-9 2-hydroxymethyl-2,3-dihydrobenzo[1,4]dioxin 

Relevant academic research and scientific papers

1,4-BENZODIOXIN CHEMISTRY : A NEW ROUTE TO C-3 FUNCTIONALIZED 2-METHYLENE-1,4-BENZODIOXANS

The building-up of C-3 functionalized 2-methylene-1,4-benzodioxan structures was achieved through zinc salt-mediated Mitsunobu substitutions carried out with a 1,4-benzodioxin-2-yl carbinol.

Synthesis of novel estrogen receptor antagonists using metal-catalyzed coupling reactions and characterization of their biological activity

Estrogen receptor (ER) antagonists are valuable in the treatment of ER-positive human breast cancer. In this study, we designed and synthesized nine new derivatives of 17β-estradiol (E2) with a bulky side chain attached to its C-7α position, and determined their ER antagonistic activity using in vitro bioassays. Four of the derivatives showed a strong inhibition of ERα transactivation activity in a luciferase reporter assay and blocked ERα interactions with coactivators. Similarly, these derivatives also strongly inhibited the growth of the ERα-positive human breast cancer cells. Computational docking analysis was conducted to model the interaction of these antagonists with the human ERα and showed that they could tightly bind to the ERα in a manner similar to that of ICI-182,780, a pure ER antagonist. These results provide an example that attachment of a bulky side chain to the C-7α position of E2 can produce ER antagonists with ER affinity comparable to that of ICI-182,780.

Substituted heterocyclic compounds, method for preparing and compositions containing same

The invention relates to compounds of formula (I): wherein: R1, R2and R3are as defined in the description, X is as defined in the description, Y represents an oxygen atom, a sulphur atom, a C(H)qgroup, SO or SO2, n is equal to from 0 to 5, A represents a NR5R6group, and medicinal products containing the same which are useful in treating or in preventing melatoninergic disorders.