23796-95-4

Upstream product

• 591-50-4 iodobenzene 
• 23653-23-8 closo-1,10-dicarbadecaborane 
• 37099-60-8 1,10-C₂B₈H₈-1-Pb(CH₃)3-10-C₆H₅ 
• 52700-85-3 1,10-C₂B₈H₈-1-COC₆H₅-10-C₆H₅ 
• 52700-87-5 1,10-C₂B₈H₈-1-COCH₃-10-C₆H₅ 
• 52700-91-1 1,10-C₂B₈H₈-1-CHO-10-C₆H₅ 
• 37099-59-5 1,10-C₂B₈H₈-1-HgCH₃-10-C₆H₅ 
• 23653-29-4 1-C₆H₅-1,6-C₂B₈H₉ 

Relevant academic research and scientific papers

Development of androgen receptor ligands by application of ten-vertex para-carborane as a novel hydrophobic core structure

We report here the design, synthesis, androgenic activity and anti-androgenic activity of novel derivatives of hexadecahedral 1,10-dicarba-closo-decaborane, which is generally called ten-vertex para-carborane. The synthesized compounds exhibited very high binding affinity for the androgen receptor and showed anti-androgenic activity toward the androgen-dependent SC-3 cell line. Two compounds also exhibited partial agonistic activity in SC-3 assay. The docking studies of carborane derivatives to AR demonstrate that ten-vertex carborane is useful for development of novel bioactive compounds as well as twelve-vertex carboranes that are well known to be versatile pharmacophores. Ten-vertex carborane, which has not previously been applied in the field of medicinal chemistry, appears to have potential as a hydrophobic pharmacophore with characteristic properties.

The polyhedral B6C2H8, B7C2H9, and B8C2H10 carboranes and their C-monomethyl and C-monophenyl derivatives

The pyrolysis of 1,3-B7C2H13 at 215° in the absence of diborane yields the B6C2H8, B7C2H9, and 1,6-B8C2H10 carboranes, while in the presence of diborane the yield of 1,6-B8C2H10 is considerably enhanced. Isomerization of 1,6-B8C2H10 to the 1,10-B8C2H10 isomer occurs at 300°. Pyrolysis of 1,3-NaB7C2H12 at 200° yields 1,7-B7C2H9. The C-monomethyl and C-monophenyl derivatives of these carboranes are also described.