238088-34-1Relevant articles and documents
A highly enantioselective and diastereoselective synthesis of cyclobutanes via boronic esters
Man, Hon-Wah,Hiscox, William C.,Matteson, Donald S.
, p. 379 - 381 (2008/02/11)
(equation presented) Deprotonation of enantiopure (R,R)-1,2-dicyclohexyl-1,2-ethanediol 1-chloro-4-cyanobutylboronates 5 with LDA followed by treatment with anhydrous magnesium bromide yields (R)-(trans-2-cyanocyclobutyl)boronic esters 7 in high diastereomeric and enantiomeric purity. No cyclobutane formation has been observed in the absence of at least a catalytic amount of magnesium halide.