23819-92-3

Usage

Uses

Used in Pharmaceutical Industry:
5-CHLORO-2-HYDROXY-4,6-DIMETHYLNICOTINONITRILE is used as an intermediate in the synthesis of pharmaceuticals for its unique structure and properties, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
5-CHLORO-2-HYDROXY-4,6-DIMETHYLNICOTINONITRILE is also used as an intermediate in the synthesis of agrochemicals, playing a role in the creation of pesticides, herbicides, and other agricultural products to improve crop yields and protect plants from pests.
Used in Organic Compounds Synthesis:
5-CHLORO-2-HYDROXY-4,6-DIMETHYLNICOTINONITRILE serves as a key intermediate in the synthesis of various organic compounds, facilitating the production of a wide range of chemical products with different applications.
Used in Medical Research and Drug Development:
Due to its unique structure and properties, 5-CHLORO-2-HYDROXY-4,6-DIMETHYLNICOTINONITRILE may have potential applications in the field of medical research and drug development, aiding in the discovery and creation of novel therapeutic agents and treatments.

InChI:InChI=1/C8H7ClN2O/c1-4-6(3-10)8(12)11-5(2)7(4)9/h1-2H3,(H,11,12)

Upstream product

• 1694-29-7 3-chloropentane-2,4-dione 
• 107-91-5 cyanoacetic acid amide 
• 123-54-6 acetylacetone 
• 769-28-8 3-Cyano-4,6-dimethyl-2(1H)-pyridon 
• 769-28-8 2-hydroxy-4,6-dimethyl-3-carbonitrile 

Downstream Products

• 91591-63-8 2,5-dichloro-4,6-dimethylpyridine-3-carbonitrile 
• 1391712-50-7 5-[3-(2,5-dichloro-4,6-dimethyl-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-2-hydroxy-3-methoxy-1-nitrobenzene 
• 1402714-41-3 5-[3-(2,5-dichloro-4,6-dimethyl-1-oxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-2-hydroxy-3-methoxy-1-nitrobenzene 
• 923287-50-7 2,5-dichloro-3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-4,6-dimethylpyridine 1-oxide 
• 175204-44-1 2,5-dichloro-4,6-dimethylnicotinamide 

Relevant academic research and scientific papers

Preparation method of dichloro dialkyl fumaronitrile

The preparation method comprises the following steps: I raw materials are taken as raw materials, and chlorine or N - chlorosuccinimide is used as a chlorination reagent for chlorination reaction to generate compound II. The condensation reaction of compound II with cyanoacetamide is carried out under the action of a base to give compound III. The compound III is chlororeacted with phosphorus oxychloride to give a dichloro dialkyl nicotinonitrile. The preparation method avoids the use of sulfonyl chloride as a chlorination reagent, thereby avoiding the generation of sulfur dioxide tail gas, and preventing the generated acid waste gas from corroding equipment and the like.

Route Of Synthesis For Opicapone

The present invention relates to a new route of synthesis for obtaining Opicapone ((4Z)-4-[3-(2,5-dichloro-4,6-dimethyl-1-oxidopyridin-1-ium-3-yl)-2H-1,2,4-oxadia-zol-5-ylidene]-2-hydroxy-6-nitrocyclohexa-2,5-dien-1-one), new intermediates in the reaction path and the new substance 2,5-dichloro-N-hydroxy-4,6-dimethylpyridine-3-carboximidoyl chloride.

A structure-activity relationship study of the positive allosteric modulator LY2033298 at the M4 muscarinic acetylcholine receptor

Positive allosteric modulators (PAMs) targeting the M4 muscarinic acetylcholine receptor (mAChR) offer greater sub-type selectivity and unique potential as central nervous system agents through their novel mode of action to traditional orthosteric ligands. In an attempt to elucidate the molecular determinants of allostery mediated by the exemplar thienopyridine M4 mAChR PAM, LY2033298, we report herein a systematic structure-activity relationship (SAR) study investigating different linkage points, halogen replacements to examine size and electronic effects, and different substitution combinations on the thienopyridine scaffold. We applied an operational model of allosterism to determine values of functional affinity (KB), cooperativity (αβ) and intrinsic agonism (τB) for all compounds.

CHEMICAL COMPOUND USEFUL AS INTERMEDIATE FOR PREPARING A CATECHOL-O-METHYLTRANSFERASE INHIBITOR

There is disclosed a methylated intermediate which may be demethylated to provide an inhibitor of catechol-O-methyltransferase useful in the treatment of Parkinson's disease. Also disclosed are methods of making and using said intermediate.

Oxadiazole derivatives as COMT inhibitors

This invention relates to novel substituted [1,2,4]-oxadiazoles, their use in the treatment of some central and peripheral nervous system disorders, methods for their preparation and pharmaceutical compositions containing them.

Synthesis of some halogen- and nitro-substituted nicotinic acids and their fragmentation under electron impact

Features of electrophilic and nucleophilic substitution under chlorination and nitration reactions conditions have been investigated for 6-hydroxy- and 6-methyl-substituted derivatives of 3-cyano-4-methyl-2(1H)-pyridones. The polychloro- and nitro-substituted 3-cyano-4-methylpyridines obtained were used as synthons in the synthesis of some polyhalo- and nitro-substituted nicotinic acids and their amides. The fragmentation pathways of the synthesized compounds under electron impact have been studied.

Herbicidal cyclohexane-1,3-dione derivatives

The invention concerns novel compounds of the formula I STR1 wherein: Z is selected from oxygen and the group --YAn wherein Y is selected from C1 to C6 alkyl and benzyl and An is an anion; k is zero or the integer 1; n is an integer selected from 3 and 4; X is selected from halogen, nitro, cyano, alkyl, substituted alkyl, hydroxy, alkoxy, substituted alkoxy, alkenyl, alkenyloxy, alkynyl, alkynyloxy, acyloxy, alkoxycarbonyl, alkylthio, alkylsulfinyl, alkylsulfonyl, sulfamoyl, substituted sulfamoyl, alkanoyloxy, benzyloxy, substituted benzyloxy, amino, substituted amino and the groups formyl and alkanoyl and the oxime, imine and Schiff base derivatives thereof; R1 is selected from hydrogen, alkyl, alkenyl, alkynyl, substituted alkyl, alkylsulfonyl, arylsulfonyl, acyl and an inorganic or organic cation; R2 is selected from alkyl, substituted alkyl, alkenyl, haloalkenyl, alkynyl and haloalkynyl; R3 is selected from alkyl, fluoroalkyl, alkenyl, alkynyl, and phenyl; and R4 is selected from hydrogen, halogen, alkyl, cyano and alkoxycarbonyl. The compounds of the invention show herbicidal properties and plant growth regulating properties and in further embodiments the invention provides processes for the preparation of compounds of formula I, intermediates useful in the preparation of the compounds of formula I, compositions containing as active ingredient a compound of formula I, and herbicidal and plant growth regulating processes utilizing compounds of formula I.