23820-76-0

Upstream product

• 64548-09-0 5α-cholest-9(11)-en-3β-ol 3-acetate 
• 114682-97-2 9-Oxo-9H-thioxanthene-3-carboxylic acid (3R,5R,8S,9R,10S,13R,14S,17R)-9-chloro-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester 
• 75415-38-2 (5R,8S,10S,13R,14S,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-1,2,4,5,6,7,8,10,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one 
• 157396-43-5 3β-acetoxy-8α,9α-epoxy-5α-cholestan-7,11-dione 
• 116282-34-9 3β-acetoxy-5α-cholestane-7,11-dione 
• 115760-46-8 11α-hydroxy-7-oxo-5α-cholest-8-en-3β-yl acetate 
• 38819-63-5 3β-acetoxy-Δ^8,9-cholesten-7-one 
• 117041-35-7 3β-acetoxy-5α-cholestan-11-one 

Relevant academic research and scientific papers

Synthesis of cytotoxic novel 9,11-secosterol analogs: Structure/activity studies

In an effort to determine the pharmaceutical utility and the structural requirements for activity against tumor cell lines, 30 novel 9,11-secosterol analogues with different side chains and degrees of oxidation at C-9 were synthesized starting from hecogenin. Evaluation of the synthesized compounds for cytotoxicity against KB, HeLa and MCF-7 cell lines revealed that some important structural features are required for activity. The presence of a cholesterol-type side chain, which appears to play a major role in determining the biological activity, the existence of a ketone functional at C-9 is also crucial for anticancer activity whereas hydroxyl/ketone function at C-22 on the side chain did not increase cytotoxicity.

THE THIOXANTHONE SYSTEM AS A TEMPLATE IN FREE RADICAL RELAY CHLORINATION OF A STEROID

The 3-α-cholestanyl ester of thioxanthone-3-carboxylic acid undergoes selective chlorination of the steroid C-9 carbon by a radical relay mechanism directed by the thioxanthone template.

High Pressure Liquid Chromatography of Sterol Benzoates

The high pressure liquid chromatographic behavior of forty sterol benzoates on a Zorbax ODS reverse phase column and on a normal phase column of Zorbax SIL is desrcibed.Keywords-HPLC; sterol benzoate; cholestadienol; phytosterol.