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23821-37-6

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23821-37-6 Usage

General Description

3-OXO-3-PYRIDIN-4-YL-PROPIONITRILE, also known as DHPN, is a chemical compound with the molecular formula C8H6N2O. It is a yellow crystalline substance commonly used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. DHPN is a versatile intermediate with high reactivity, making it a valuable building block in chemical synthesis. It is known for its strong nitrile function and pyridine ring, which contribute to its diverse applications in the field of organic chemistry. DHPN is also used as a starting material in the preparation of various heterocyclic compounds, making it an important compound in the pharmaceutical and chemical industries.

Check Digit Verification of cas no

The CAS Registry Mumber 23821-37-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,8,2 and 1 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 23821-37:
(7*2)+(6*3)+(5*8)+(4*2)+(3*1)+(2*3)+(1*7)=96
96 % 10 = 6
So 23821-37-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H6N2O/c9-4-1-8(11)7-2-5-10-6-3-7/h2-3,5-6H,1H2

23821-37-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-oxo-3-pyridin-4-ylpropanenitrile

1.2 Other means of identification

Product number -
Other names 3-Oxo-3-(4-pyridinyl)propanenitrile

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:23821-37-6 SDS

23821-37-6Relevant articles and documents

SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS

-

Page/Page column 45, (2022/02/15)

This disclosure is drawn to substituted pyridine compounds and compositions, and associated methods, useful for inhibition of SARM1 activity and/or for treating or preventing a neurological diseases.

Identification of diphenylalkylisoxazol-5-amine scaffold as novel activator of cardiac myosin

Boggu, Pulla Reddy,Venkateswararao, Eeda,Manickam, Manoj,Sharma, Niti,Kang, Jong Seong,Jung, Sang-Hun

, (2020/09/16)

To identify novel potent cardiac myosin activator, a series of diphenylalkylisoxazol-5-amine compounds 4–7 have been synthesized and evaluated for cardiac myosin ATPase activation. Among the 37 compounds, 4a (CMA at 10 μM = 81.6%), 4w (CMA at 10 μM = 71.2%) and 6b (CMA at 10 μM = 67.4%) showed potent cardiac myosin activation at a single concentration of 10 μM. These results suggested that the introduction of the amino-isoxazole ring as a bioisostere for urea group is acceptable for the cardiac myosin activation. Additional structure–activity relationship (SAR) studies were conducted. Para substitution (-Cl, –OCH3, -SO2N(CH3)2) to the phenyl rings or replacement of a phenyl ring with a heterocycle (pyridine, piperidine and tetrahydropyran) appeared to attenuate cardiac myosin activation at 10 μM. Additional hydrogen bonding acceptor next to the amino group of the isoxazoles did not enhance the activity. The potent isoxazole compounds showed selectivity for cardiac myosin activation over skeletal and smooth muscle myosin, and therefore these potent and selective isoxazole compounds could be considered as a new series of cardiac myosin ATPase activators for the treatment of systolic heart failure.

NOVEL PYRAZOLO-PYRROLO-PYRIMIDINE-DIONE DERIVATIVES AS P2X3 INHIBITORS

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Page/Page column 102, (2019/05/15)

The present invention covers substituted Pyrazolo-pyrrolo-pyrimidine-dione (PPPD) compounds of general formula (I): in which R1, R2 and R3 are as defined herein, methods of preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of neurogenic diseases, as a sole agent or in combination with other active ingredients.

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