23832-72-6Relevant academic research and scientific papers
A convenient one-pot synthesis of 1-aryl-substituted 2H-isoquinolin-3-ones
Méndez, Leticia J.,Cánepa, Alicia S.,González, M. Gloria,Bravo, Rodolfo D.
experimental part, p. 688 - 690 (2012/02/15)
The synthesis of 1-aryl-substituted 2H-isoquinolin-3-ones is studied from 2-cyanomethylbenzoic acid and substituted benzenes via Friedel-Crafts acylation and intramolecular cyclization of 2-acylphenylacetonitriles formed in a one-pot method using sulfated zirconia as catalysts. Short reaction times, simplicity of operation, and easy work-up are some advantages of this method.
Expedient synthesis of 3-hydroxyisoquinolines and 2-hydroxy-1,4- naphthoquinones via one-pot aryne acyl-alkylation/condensation
Allan, Kevin M.,Hong, Boram D.,Stoltz, Brian M.
supporting information; experimental part, p. 4960 - 4964 (2010/02/15)
A convenient method is disclosed for the synthesis of both 3-hydroxyisoquinolines and 2-hydroxy-1,4-naphthoquinones from β-ketoesters using a one-pot aryne acyl-alkylation/condensation procedure. When performed in conjunction with a one-step method for the synthesis of the β-ketoester substrates, this method provides a new route to these polyaromatic structures in only two steps from commercially available carboxylic acid starting materials. The utility of this approach is demonstrated in the synthesis of the atropisomeric P,N-ligand, QUINAP. The Royal Society of Chemistry 2009.
A novel synthesis of 1-substituted 2H-isoquinolin-3-ones
Canepa, Alicia S.,Bravo, Rodolfo D.
, p. 979 - 982 (2007/10/03)
The intramolecular cyclization of 2-acylphenylacetonitriles 1 under strongly acidic conditions easily affords 1-substituted 2H-isoquinolin-3-ones 2 in excellent yields.
