238398-36-2

Upstream product

• 784183-53-5 2,2,2-trifluoro-N-(2-iodo-4-methylphenyl)acetamide 
• 52670-38-9 2-ethynylaniline 
• 1176667-08-5 C₁₇H₁₃F₃N₂O 
• 25428-06-2 2-amino-5-methyl-acetophenone 

Downstream Products

• 1449134-94-4 1-((2'R,3'S)-3'-chloro-6-methyl-2-phenylspiro[benzo[d][1,3]oxazine-4,2'-indolin]-1'-yl)ethanone 
• 1449135-06-1 N-(2-(1-acetyl-1H-indol-2-yl)-4-methylphenyl)benzamide 
• 238398-49-7 2-(2-acetylamino-5-methylphenyl)-3-nitrosoindole 
• 238398-55-5 2-(2-amino-5-methylphenyl)-3-nitrosoindole 
• 543745-49-9 [2-(1H-indol-2-yl)-4-methylphenyl]-urea 
• 238398-43-1 2-(2-acetylamino-5-methylphenyl)indole 

Relevant academic research and scientific papers

Synthesis of indolo[1,2-c]quinazolines from 2-alkynylaniline derivatives through Pd-catalyzed indole formation/cyclization with N,N-dimethylformamide dimethyl acetal

An efficient strategy for the synthesis of 6-unsubstituted indolo[1,2-c]quinazolines is described. The Pd-catalyzed reaction of o-(oaminophenylethynyl) trifluoroacetanilides with Ar-B(OH)2 afforded 2-(o-aminophenyl)-3-arylindoles, that were converted to 1

Palladium(II)-catalyzed cycloamidination via C(sp2)-H activation and isocyanide insertion

An efficient method for the synthesis of nitrogen heterocycles containing a cyclic amidine moiety has been developed. The process involves palladium-catalyzed C(sp2)-H activation and isocyanide insertion starting with readily accessible ortho-heteroarene-substituted aniline derivatives under mild conditions. Copyright

Platinum-catalyzed formal Markownikoff's hydroamination/hydroarylation cascade of terminal alkynes assisted by tethered hydroxyl groups

(Chemical Equation Presented) An efficient method for Markownikoff's hydroamination-hydroarylation of alkynols using PtBr2 as catalyst has been developed. The platinum-catalyzed reactions of alkynols with amino group containing aromatics were a

Studies of the reactions between indole-2,3-diones (isatins) and 2-aminobenzylamine

Reflux of equimolecular amounts 2-aminobenzylamine and isatins in acetic acid produced indolo[3,2-c]quinolin-6-ones in good yields. A proposed mechanism involving initial formation of a spiro compound is given. This isolable intermediate subsequently rearranges via a sequential isocyanate ring opening and a cyclisation process to a urea derivative which finally cyclized to the indolo[3,2-c]quinolin-6-ones. The urea derivative could be prepared separately and cyclized selectively to indolo[3,2-c]quinolin-6-one. Reaction of N-acetylisatin with 2-aminobenzylamine at room temperature yielded the 1,4-benzodiazepinone 3-(2-acetamidophenyl)-1,5-dihydro-1,4-benzodiazepin-2-one whereas its isomer 2(2-acetamidophenyl)-4,5-dihydro-1,4-benzodiazepin-3-one was obtained from 2-(2-acetylaminophenyl)-N-(2-aminobenzyl)-2-oxoacetamide in acetic acid at room temperature. The previously unknown linear isomer of indolo[3,2-c]quinolin-6-one, i.e. indolo[2,3-b]quinolin-11-one, has been prepared by thermal (260°C) cyclization of methyl 2-phenylamino indole-3-carboxylate, which in turn was prepared in two steps from methyl indole-3-carboxylate.

Derivatives of the new ring system indolo[1,2-c]benzo[1,2,3]triazine with potent antitumor and antimicrobial activity

Derivatives of the new ring system indolo[1,2-c]benzo[1,2,3]triazine 5 were synthesized by diazotization of substituted 2-(2-aminophenyl)indoles followed by an intramolecular coupling reaction of the diazonium group with the indole nitrogen. To obtain the