238403-53-7Relevant academic research and scientific papers
Synthesis and Structural Characteristics of all Mono- And Difluorinated 4,6-Dideoxy- d - Xylo-hexopyranoses
Briggs, Edward L.,Fontenelle, Clement Q.,Kuppala, Ramakrishna,Light, Mark E.,Linclau, Bruno,Szpera, Robert,Vendeville, Jean-Baptiste,Wells, Neil J.,Wheatley, David E.
, p. 7725 - 7756 (2021/06/28)
Protein-carbohydrate interactions are implicated in many biochemical/biological processes that are fundamental to life and to human health. Fluorinated carbohydrate analogues play an important role in the study of these interactions and find application a
Addressing the Structural Complexity of Fluorinated Glucose Analogues: Insight into Lipophilicities and Solvation Effects
St-Gelais, Jacob,C?té, émilie,Lainé, Danny,Johnson, Paul A.,Giguère, Denis
supporting information, p. 13499 - 13506 (2020/10/02)
In this work, we synthesized all mono-, di-, and trifluorinated glucopyranose analogues at positions C-2, C-3, C-4, and C-6. This systematic investigation allowed us to perform direct comparison of 19F resonances of fluorinated glucose analogues and also to determine their lipophilicities. Compounds with a fluorine atom at C-6 are usually the most hydrophilic, whereas those with vicinal polyfluorinated motifs are the most lipophilic. Finally, the solvation energies of fluorinated glucose analogues were assessed for the first time by using density functional theory. This method allowed the log P prediction of fluoroglucose analogues, which was comparable to the C log P values obtained from various web-based programs.
Overproduction of CMP-sialic acid synthetase for organic synthesis
Liu, Jennifer Lin-Chun,Shen, Gwo-Jenn,Ichikawa, Yoshitaka,Rutan, James F.,Zapata, Gerardo,Vann, Willie F.,Wong, Chi-Huey
, p. 3901 - 3910 (2007/10/02)
The gene coding for Escherichia coli CMP-sialic acid synthetase (E.G. 2.7.7.43) was cloned and overexpressed in E. coli through a primer-directed polymerase chain reaction. Two plasmids were constructed to produce the native enzyme and a modified enzyme f
The synthesis and hydrolysis of a series of deoxy- and deoxyfluoro-α-D-"glucopyranosyl" phosphates
Withers, Stephen G.,Percival, M. David,Street, Ian P.
, p. 43 - 66 (2007/10/02)
The syntheses of three deoxy-α-D-"glucopyranosyl" phosphates and a series of dideoxymonofluoro- and dideoxydifluoro-α-D-glucopyranosyl phosphates are described.Rate constants for their acid-catalyzed hydrolysis were determined.Deoxygenation in the sugar r
