238432-36-5

Basic information

• Product Name: toluene-4-sulfonic acid 5-(2-methyl-[1,3]dioxolan-2-yl)-pentyl ester
• CAS NO: 238432-36-5
• Molecular Weight: 328.43
• Mol File: 238432-36-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: toluene-4-sulfonic acid 5-(2-methyl-[1,3]dioxolan-2-yl)-pentyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: toluene-4-sulfonic acid 5-(2-methyl-[1,3]dioxolan-2-yl)-pentyl ester(238432-36-5)
• EPA Substance Registry System: toluene-4-sulfonic acid 5-(2-methyl-[1,3]dioxolan-2-yl)-pentyl ester(238432-36-5)

Safety Data

• Hazardous Substances Data: 238432-36-5(Hazardous Substances Data)

Upstream product

• 2046-21-1 methyl 6-oxoheptanoate 
• 145068-76-4 methyl 5-(2-methyl-1,3-dioxolan-2-yl)pentanoate 
• 3128-07-2 6-oxoheptanoic acid 
• 36651-23-7 5-(2-methyl-[1,3]dioxolan-2-yl)-pentan-1-ol 
• 98-59-9 p-toluenesulfonyl chloride 

Relevant articles and documents

Potentiation of cADPR-induced Ca2+-release by methylxanthine analogues

Caffeine and other methylxanthines are known to induce Ca2+-release from intracellular stores via the ryanodine receptor. In the present work, a range of caffeine analogues, in which methyl groups at the 1 and 7 positions were replaced with alkyl chains containing different functional groups (oxo, hydroxyl, propargyl, ester, and acids), were synthesized. These compounds were then screened for their ability to potentiate Ca2+-release induced by cADPR (an endogenous modulator of ryanodine receptors) in sea urchin egg homogenates. Two of the synthesized methylxanthines, 1,3-dimethyl-7-(7- hydroxyoctyl)xanthine (37) and 3-methyl-7-(7-oxooctyl)-1-propargylxanthine (66), were shown to be more potent than caffeine in potentiating cADPR- induced Ca2+-release, while 1,3-dimethyl-7-(5-ethylcarboxypentyl)xanthine (14) was shown to be more efficacious. The development of new methylxanthine analogues may lead to a better understanding of ryanodine receptor function and could possibly provide novel therapeutic agents.