23844-56-6

Usage

Uses

MCPP Methyl Ester is a pesticide residue analyzed in foodstuffs.

InChI:InChI=1/C10H11ClO3/c1-7(10(12)13-2)14-9-5-3-8(11)4-6-9/h3-7H,1-2H3

Upstream product

• 17639-93-9 2-chloro-propionic acid methyl ester 
• 52106-86-2 sodium 4-chloro-2-methyl-phenolate 
• 5445-17-0 Methyl 2-bromopropionate 
• 1570-64-5 2-methyl-4-chlorophenol 

Downstream Products

• 16484-77-8 (R)-Mecoprop 
• 25333-13-5 (S)-mecoprop 
• 115304-96-6 (S)-mecoprop methyl ester 
• 115304-95-5 2-[4-chloro-2-methylphenoxy]propionic acid methyl ester 
• 36304-48-0 2-(4-Chloro-2-methyl-phenoxy)-propionic acid hydrazide 

Relevant academic research and scientific papers

Insight into solid-liquid phase transfer catalyzed synthesis of Mecoprop ester using K 2CO 3 as base and development of new kinetic model involving liquid product and two solid co-products

Abstract: 2-Methyl-4-chlorophenoxy propionic acid (Mecoprop) is a widely used household herbicide. In the current work, a simple synthetic method is developed for Mecoprop methyl ester using solid-liquid phase transfer catalysis (S-L PTC) with K 2CO 3 as mild base and toluene as solvent. Conversion of 95% was achieved with 100% selectivity for Mecoprop ester at 100°C. Simple isolation process was employed to recover the product from the reaction mixture. A reaction mechanism was proposed and new kinetic model developed involving one liquid and two solid co-products. The activation energy for the reaction was calculated. This is the first example of its kind being reported vis-à-vis kinetics and mechanism. Graphical Abstract: Solid-liquid phase transfer catalyzed (S-L PTC) O-alkylation of 4-chloro-2-methyl phenol is done at relatively mild conditions to form methyl 2-(4-chloro-2-methylphenoxy) propionate (Mecoprop methyl ester). New insight on reaction mechanism and kinetics is presented.

Synthesis and biological evaluation of novel Ani9 derivatives as potent and selective ANO1 inhibitors

Anoctamin 1 (ANO1), a calcium-activated chloride channel, is highly expressed and amplified in a number of carcinomas including breast, pancreatic and prostate cancers. Downregulation of ANO1 expression and function significantly inhibits cell proliferation, migration, and invasion of various cancer cell lines. Development of potent and selective ANO1 inhibitors is currently desirable, which may provide a new strategy for cancer treatment. Our previous study revealed a new class of ANO1 inhibitor, (E)-2-(4-chloro-2-methylphenoxy)-N'-(2-methoxybenzylidene)acetohydrazide (Ani9) and structural optimization via chemical modification of Ani9 basic skeleton was undertaken for the development of more potent and specific inhibitors of ANO1. Structure-activity relationship studies with newly synthesized derivatives revealed a number of potent ANO1 inhibitors, among which 5f is the most potent inhibitor with an IC50 value of 22 nM. The selectivity analyses showed that 5f has excellent selectivity to ANO1 (>1000-fold over ANO2). In cellular assays, 5f significantly inhibited cell proliferation of PC3, MCF7, and BxPC3 cells expressing high levels of ANO1. In addition, 5f strongly reduced the protein levels of ANO1 in PC3 cells. This study will be useful in the development of ANO1 inhibitors for treatment of cancer and other ANO1-related diseases.

Preparation of aliphatic/aromatic ethers

Aliphatic/aromatic ethers are prepared by reacting an aliphatic halide with either an alkali or alkaline earth metal, or ammonium phenolate or naphtholate, in an inert organic solvent, and in the presence of at least one tertiary amine sequestering agent having the formula: