23845-96-7

Basic information

• Product Name: 2-BENZYLOXY-PYRIDIN-3-YLAMINE
• Synonyms: 3-AMINO-2-BENZYLOXYPYRIDINE;2-BENZYLOXY-PYRIDIN-3-YLAMINE;2-(Phenylmethoxy)-3-pyridinamine;Pyridine,3-amino-2-(benzyloxy)- (8CI)
• CAS NO: 23845-96-7
• Molecular Formula: C₁₂H₁₂N₂O
• Molecular Weight: 200.24
• Product Categories: Pyridine;pharmacetical
• Mol File: 23845-96-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-BENZYLOXY-PYRIDIN-3-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BENZYLOXY-PYRIDIN-3-YLAMINE(23845-96-7)
• EPA Substance Registry System: 2-BENZYLOXY-PYRIDIN-3-YLAMINE(23845-96-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 23845-96-7(Hazardous Substances Data)

Usage

General Description

2-BENZYLOXY-PYRIDIN-3-YLAMINE is a chemical compound with the molecular formula C15H14N2O. It is an amine derivative with a benzyl ether substituent attached to the pyridine ring. 2-BENZYLOXY-PYRIDIN-3-YLAMINE is commonly used as a building block in organic synthesis and pharmaceutical research. It has potential applications in the development of various drugs and biologically active molecules due to its unique structure and reactivity. 2-BENZYLOXY-PYRIDIN-3-YLAMINE can also be utilized as a reagent in chemical reactions to create complex organic molecules with specific properties and functions.

Upstream product

• 5470-18-8 2-Chloro-3-nitropyridine 
• 100-51-6 benzyl alcohol 
• 111301-96-3 2-(benzyloxy)-3-nitropyridine 

Downstream Products

• 1415151-96-0 2-(2-(benzyloxy)pyridin-3-ylamino)-9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-purin-8(9H)-one 
• 6298-19-7 2-chloro-3-aminopyridine 

Relevant articles and documents

Identification of 2-Imidazopyridine and 2-Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases

Janus kinases (JAKs) have a key role in regulating the expression and function of relevant inflammatory cytokines involved in asthma and chronic obstructive pulmonary disease. Herein are described the design, synthesis, and pharmacological evaluation of a series of novel purinone JAK inhibitors with profiles suitable for inhaled administration. Replacement of the imidazopyridine hinge binding motif present in the initial compounds of this series with a pyridone ring resulted in the mitigation of cell cytotoxicity. Further systematic structure-activity relationship (SAR) efforts driven by structural biology studies led to the discovery of pyridone 34, a potent pan-JAK inhibitor with good selectivity, long lung retention time, low oral bioavailability, and proven efficacy in the lipopolysaccharide-induced rat model of airway inflammation by the inhaled route.

PROCESS FOR PRODUCING AROMATIC AMINE HAVING ARALKYLOXY OR HETEROARALKYLOXY GROUP

There is provided a process for producing an aromatic amine compound having an aralkyloxy or heteroaralkyloxy group, in which an aromatic nitro compound having an aralkyloxy or heteroaralkyloxy group is reacted with hydrogen under mild conditions in accordance with a simple procedure while preventing the removal of aralkyl or heteroaralkyl group and keeping stable the other substituents on the aryl group or heteroaryl group so that the substituent does not take part in the reaction, to selectively reduce only the nitro group. The present invention is directed to a process for producing an aromatic amine compound which comprises reacting an aromatic nitro compound represented by the general formula (1): wherein Ar represents an aryl group or heteroaryl group which may have a substituent, and Z represents a divalent aromatic group which may have a substituent, with hydrogen in the presence of a metal catalyst to obtain an aromatic amine compound represented by the general formula (2): wherein Ar and Z have the meaning as defined above.