2385-76-4Relevant academic research and scientific papers
Nickel-catalyzed hydrogenolysis of unactivated carbon-cyano bonds
Patra, Tuhin,Agasti, Soumitra,Modak, Atanu,Maiti, Debabrata
, p. 8362 - 8364 (2013)
Selective hydrogenolysis of C-CN bonds can allow chemists to take advantage of ortho-directing ability, α-C-H acidity and electron withdrawing ability of the cyano group for synthetic manipulations. We have discovered hydrogenolysis of aryl and aliphatic cyanides under just 1 bar of hydrogen by using a nickel catalyst. This protocol was applied in the aryl cyanide directed functionalization reaction and α-substitution of benzyl cyanides.
