23862-33-1

Upstream product

• 1121-89-7 piperidine-2,6-dione 
• 103-63-9 1-phenyl-2-bromoethane 
• 111-29-5 1 ,5-pentanediol 
• 64-04-0 phenethylamine 
• 110-94-1 1,5-pentanedioic acid 

Relevant academic research and scientific papers

Diphenyliodonium Ion/Et3N Promoted Csp2-H Radical Phosphorylation of Enamides

This work reports a simple and efficient method for the direct phosphorylation of enamide under metal-free conditions. The P-centered radicals, derived from secondary phosphine oxides, are generated under mild reaction conditions in the presence of diphenyliodonium salt and Et3N and are introduced onto a range of enamides in good isolated yields. The method features broad substrate scope, good functional group tolerance, and efficient scale-up.

Synthesis of Cyclic Imides by Acceptorless Dehydrogenative Coupling of Diols and Amines Catalyzed by a Manganese Pincer Complex

The first example of base-metal-catalyzed dehydrogenative coupling of diols and amines to form cyclic imides is reported. The reaction is catalyzed by a pincer complex of the earth abundant manganese and forms hydrogen gas as the sole byproduct, making the overall process atom economical and environmentally benign.

MANGANESE BASED COMPLEXES AND USES THEREOF FOR HOMOGENEOUS CATALYSIS

The present invention relates to novel manganese complexes and their use, inter alia, for homogeneous catalysis in (1) the preparation of imine by dehydrogenative coupling of an alcohol and amine; (2) C-C coupling in Michael addition reaction using nitriles as Michael donors; (3) dehydrogenative coupling of alcohols to give esters and hydrogen gas (4) hydrogenation of esters to form alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di- lactones), or polyesters); (5) hydrogenation of amides (including cyclic dipeptides, lactams, diamide, polypeptides and polyamides) to alcohols and amines (or diamine); (6) hydrogenation of organic carbonates (including polycarbonates) to alcohols or hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (7) dehydrogenation of secondary alcohols to ketones; (8) amidation of esters (i.e., synthesis of amides from esters and amines); (9) acylation of alcohols using esters; (10) coupling of alcohols with water and a base to form carboxylic acids; and (11) preparation of amino acids or their salts by coupling of amino alcohols with water and a base. (12) preparation of amides (including formamides, cyclic dipeptides, diamide, lactams, polypeptides and polyamides) by dehydrogenative coupling of alcohols and amines; (13) preparation of imides from diols.

Stereochemical Studies on Protonated Bridgehead Amines. 1H NMR Determination of Cis and Trans B-C Ring-Fused Structures for Salts of Hexahydropyrroloisoquinolines and Related C Ring Homologues. Capture of Unstable Ring-Fused Structures in the Solid

Acid-addition salts of tricyclic isoquinolines 2a/b, 3a/b ,4a-4c, 5, 6a/b, 7, 8a/b, 9a/b, and 17a/b were studied by high-field 1H NMR in CDCl3 solution.Cis (e.g., 14 and 15 in Figure 1) and trans (e.g., 13) B-C ring-fused structures were identified by usi